Genetics and genomics etiology of nonsyndromic orofacial clefts

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dc.contributor.authorAdeyemo, W.L.
dc.contributor.authorButali, A.
dc.date.accessioned2019-10-18T17:00:03Z
dc.date.available2019-10-18T17:00:03Z
dc.date.issued2017-01-01
dc.descriptionStaff publicationsen_US
dc.description.abstractOrofacial clefts (OFC) are complex birth defects. Seventy percent of all clefts are classified as nonsyndromic, where no recognizable structural defects other than cleft are seen. The remaining 30% are syndromic, where a cleft presents with a consistently defined structural anomaly; these are usually Mendelian in nature. Studies using contemporary genomic techniques, bioinformatics, and statistical analyses have led to appreciable advances in identifying the causes of syndromic forms of clefts. Meanwhile, only modest progress has been recorded for nonsyndromic clefts. This commentary gives an overview of the important cleft gene discoveries found using various genomic methods and tools. At the end we discuss the discoveries’ value for genetic counseling and as foundations for future research.en_US
dc.identifier.citationAdeyemo, W.L. and Butali, A. (2017). Genetics and genomics etiology of nonsyndromic orofacial clefts. Mol Gen Gen Med, Vol.1(1).en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6386
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesMol Gen Gen Med;Vol.1(1)
dc.subjectGeneticsen_US
dc.subjectGenomicsen_US
dc.subjectOrofacial cleftsen_US
dc.subjectResearch Subject Categories::ODONTOLOGYen_US
dc.titleGenetics and genomics etiology of nonsyndromic orofacial cleftsen_US
dc.typeArticleen_US
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