Fiber-enriched biscuit enhances insulin secretion, modulates b-cell function, improves insulin sensitivity, and attenuates hyperlipidemia in diabetic rats
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Date
2013-02-19
Authors
Ebuehi, O.A.T.
Journal Title
Journal ISSN
Volume Title
Publisher
PharmaNutrition
Abstract
The nutritional properties of developed fiber-enriched biscuits and its antidiabetic potentials were
investigated in alloxan-induced diabetic rats. Fiber-enriched biscuit was developed from selected fruits.
Its nutritional and antinutrient properties were investigated. Diabetes was induced in rats by a single
intraperitoneal injection of alloxan and the formulated biscuit was fed to the treatment group. The rats
were monitored daily for food intake, and body weight. Their blood glucose levels were monitored on
weekly basis. They were sacrificed by cervical dislocation after a 2-week treatment. Blood serum and
hepatic tissues were analyzed to evaluate serum insulin level, insulin resistance, insulin sensitivity,b-cell
function, and lipid profile. Histological study was carried out on pancreatic tissues. No significant
difference was observed in diet intake among the experimental groups. However, all groups except the
treated had significant (p < 0.05) weight lost. Feeding on the formulated biscuits led to a significant
reduction of blood glucose level, total cholesterol and LDL compared to the diabetic group. It also
increased serum insulin level, improved b-cell function and reduced insulin resistance as well as
restoration of pancreatic b cells. Feeding on fiber-enriched biscuit showed potent antidiabetic property
as evident by the reduced blood glucose, increased serum insulin, and increased high-density-lipoprotein
cholesterol levels.
Description
Keywords
Fiber, Antidiabetic, b-Cell function, Insulin, resistance, Hyperlipidemia
Citation
Ochuko L. Erukainure, Osaretin A.T. Ebuehi, Folasade O. Adeboyejo, Ebele N. Okafor, Aliyu Muhammad, Gloria N. Elemo