Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition

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dc.contributor.authorAlaribe, C.S.
dc.contributor.authorEsposito, T.
dc.contributor.authorSansone, F.
dc.contributor.authorAdesegun, S.
dc.contributor.authorPagano, I.
dc.contributor.authorPiccinelli, A.L.
dc.contributor.authorCelano, R.
dc.contributor.authorRubio, O.C.
dc.contributor.authorCoker, H.A
dc.contributor.authorNabavi, S.M.
dc.contributor.authorRastrelli, L.
dc.contributor.authorPicerno, P.
dc.date.accessioned2022-01-16T20:04:16Z
dc.date.available2022-01-16T20:04:16Z
dc.date.issued2019
dc.description.abstractPropolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4and7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together with a promising antidiabetic effect againsta-amylase and a-glucosidase enzymes. Finally, NP showed also a moderate inhibitionof Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products.en_US
dc.identifier.citationAlaribe, C. S., Esposito, T., Sansone, F., Sunday, A., Pagano, I., Piccinelli, A. L., ... & Picerno, P. (2019). Nigerian propolis: Chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition. Natural product research, 1-5.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10474
dc.language.isoenen_US
dc.publisherTaylor & Francis Groupen_US
dc.subjectNigerian propolisen_US
dc.subjectpolyphenolsen_US
dc.subjecta-amylase and a-glucosidase enzymesen_US
dc.subjectHelicobacter pylorien_US
dc.titleNigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibitionen_US
dc.typeArticleen_US
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