Cardiac surgery-associated acute kidney injury in a developing country: Prevalence, risk factors and outcome

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dc.contributor.authorEkure, E.N.
dc.contributor.authorEsezobor, C.I.
dc.contributor.authorSridhar, A.
dc.contributor.authorVasudevan, J.
dc.contributor.authorSubramanyan, R.
dc.contributor.authorCherian, K.M.
dc.date.accessioned2019-11-12T12:22:04Z
dc.date.available2019-11-12T12:22:04Z
dc.date.issued2015-05
dc.descriptionStaff publicationsen_US
dc.description.abstractLittle is known about cardiac surgery-associated acute kidney injury (CS-AKI) in children in developing regions of the world. The study aimed to determine the prevalence of CS- AKI, associated factors and its impact on mortality and utilization of hospital services. The hospital records of children aged 0–17 years who underwent CS at an Indian hospital were reviewed. CS-AKI was defined as a rise in serum creatinine of ≥0.3 mg/dL in any 48 h and or by urine output <0.5 mL/kg/h for an 8-h period in the first five days after CS. The study included 323 children with a median age of one year (0.04–17), of whom 22 (6.8%) were neonates and 18.3% had a single ventricle. About 60% of the children had Risk Adjusted Congenital Heart Surgery–I category 1 or 2 interventions. CS-AKI occurred in 39 children (12.1%). Factors associated with CS-AKI were sepsis and intra- and post-operative hypotension. In-hospital mortality was six-fold higher in children who developed CS-AKI. CS-AKI was associated with two to three days more of mechanical ventilation and Intensive care unit stay. CS-AKI occurs in children in developing countries, but at a lower frequency mainly due to the predominance of post-neonatal children undergoing less-complex CSs. CS-AKI was associated with higher in-hospital mortality and increased utilization of hospital services. Factors associated with CS-AKI included intra- and post-operative hypotension and sepsis.en_US
dc.identifier.citationEkure EN, Esezobor CI, Sridhar A, Vasudevan J, Subramanyan R, Cherian KM. Cardiac surgery-associated acute kidney injury in a developing country: Prevalence, risk factors and outcome. Saudi J Kidney Dis Transpl. 2015 May-Jun;26(3):489-96.en_US
dc.identifier.otherdoi: 10.4103/1319-2442.157328
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6831
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofseriesSaudi J Kidney Dis Transpl.;Vol.26(3)
dc.subjectCardiac surgeryen_US
dc.subjectAcute kidney injuryen_US
dc.subjectdeveloping countryen_US
dc.subjectPrevalenceen_US
dc.subjectRisk factorsen_US
dc.subjectOutcomeen_US
dc.subjectCongenital heart diseaseen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleCardiac surgery-associated acute kidney injury in a developing country: Prevalence, risk factors and outcomeen_US
dc.typeArticleen_US
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