Incidence, clinical outcome and risk factors of intensive care unit infections in the lagos university teaching hospital (luth), lagos, nigeria

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dc.contributor.authorIwuafor, A.A.
dc.contributor.authorOgunsola, .F.T.
dc.contributor.authorOladele, R.O.
dc.contributor.authorOduyebo, O.O.
dc.contributor.authorDesalu, I.
dc.contributor.authorEgwuatu, C.C.
dc.contributor.authorNnachi, A.U.
dc.contributor.authorAkujobi, C.N.
dc.contributor.authorIta, O.I.
dc.contributor.authorOgban, G.I.
dc.date.accessioned2019-12-05T09:49:40Z
dc.date.available2019-12-05T09:49:40Z
dc.date.issued2016-10-24
dc.descriptionStaff publicationsen_US
dc.description.abstractBackground Infections are common complications in critically ill patients with associated significant morbidity and mortality. Aim This study determined the prevalence, risk factors, clinical outcome and microbiological profile of hospital-acquired infections in the intensive care unit of a Nigerian tertiary hospital. Materials and Methods This was a prospective cohort study, patients were recruited and followed up between September 2011 and July 2012 until they were either discharged from the ICU or died. Antimicrobial susceptibility testing of isolates was done using CLSI guidelines. Results Seventy-one patients were recruited with a 45% healthcare associated infection rate representing an incidence rate of 79/1000 patient-days in the intensive care unit. Bloodstream infections (BSI) 49.0% (22/71) and urinary tract infections (UTI) 35.6% (16/71) were the most common infections with incidence rates of 162.9/1000 patient-days and 161.6/1000 patient-days respectively. Staphylococcus aureus was the most common cause of BSIs, responsible for 18.2% of cases, while Candida spp. was the commonest cause of urinary tract infections, contributing 25.0% of cases. Eighty percent (8/10) of the Staphylococcus isolates were methicillin-resistant. Gram-negative multidrug bacteria accounted for 57.1% of organisms isolated though they were not ESBL-producing. Use of antibiotics (OR = 2.98; p = 0.03) and surgery (OR = 3.15, p<0.05) in the month preceding ICU admission as well as urethral catheterization (OR = 5.38; p<0.05) and endotracheal intubation (OR = 5.78; p< 0.05) were risk factors for infection. Conclusion Our findings demonstrate that healthcare associated infections is a significant risk factor for ICU-mortality and morbidity even after adjusting for APACHE II score.en_US
dc.identifier.citationIwuafor, AA. Ogunsola, F.T., Oladele, R.O., Oduyebo, O.O., Desalu, I., Egwuatu, C.C., Nnachi, A.U., Akujobi, C.N., Ita, I.O., Ogban, G.I. Incidence, Clinical Outcome and Risk Factors of Intensive Care Unit Infections in the Lagos University Teaching Hospital (LUTH), Lagos, Nigeria. PLoS ONE 2016; 11(10): e0165242. doi:10.1371/journal.pone.0165242en_US
dc.identifier.urihttps://www.google.com/search?sxsrf=ACYBGNTgg4w2tw0AwQnJifTXOnBxHkTDCw%3A1575462033554&ei=kaTnXbyxIaydlwTM6oDoAw&q=Incidence%2C+Clinical+Outcome+and+Risk+Factors+of+Intensive+Care+Unit+Infections+in+the+Lagos+University+Teaching+Hospital+%28LUTH%29%2C+Lagos%2C+Nigeria&oq=Incidence%2C+Clinical+Outcome+and+Risk+Factors+of+Intensive+Care+Unit+Infections+in+the+Lagos+University+Teaching+Hospital+%28LUTH%29%2C+Lagos%2C+Nigeria&gs_l=psy-ab.3..0i71l8.106953.106953..108230...0.4..0.0.0.......1....2j1..gws-wiz.hcuLEHK-IZQ&ved=0ahUKEwj8vfe2_ZvmAhWszoUKHUw1AD0Q4dUDCAs&uact=5
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7039
dc.language.isoenen_US
dc.publisherPlos oneen_US
dc.relation.ispartofseries. PLoS ONE;Vol.11(10)
dc.subjectInfectionsen_US
dc.subjectPatientsen_US
dc.subjectMortalityen_US
dc.subjectHospitalen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleIncidence, clinical outcome and risk factors of intensive care unit infections in the lagos university teaching hospital (luth), lagos, nigeriaen_US
dc.typeArticleen_US
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