Haematological Properties of Aqueous Extracts of Phyllantus amarus (Schum and Thonn.) and Xylopia aethiopica (Dunal) A. Rich in Albino rats

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dc.contributor.authorTaiwo, I. A.
dc.contributor.authorOboh, B.O.
dc.contributor.authorFrancis-Garuba, P. N.
dc.date.accessioned2019-09-05T10:07:43Z
dc.date.available2019-09-05T10:07:43Z
dc.date.issued2009
dc.description.abstractA study on haematological effects of aqueous extracts from Phyllantus amarusand Xylopia aethiopica was investigated in albino rats. The extracts from both plants caused a dose-dependent decrease in erythrocyte sedimentation rate (ESR) with 400mg/kg of X. aethiopicacausing the least ESR of 2.7±0.6mm/hr. Significant increases were obtained in red blood cell (RBC) count especially with 100mg/kg of P. amarusand X. aethiopicathat caused 5.6% and 7.8% increases in RBC count respectively (P< 0.05). Similar pattern of result was obtained for packed cell volume (PCV). P. amarusdid not appear to affect haemoglobin concentration, but higher values of HB concentration were obtained for X. aethiopica; the difference was, however, not significantly different from the control (P>0.05).Total and differential count studies showed significant increases in the number of circulating leucocytes and neutrophils respectively especially with 100mg/kg of extracts (P<0.05). Assessment of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) gave significantly higher values of ALT for P. amarus – treated rats (P < 0.05). It was therefore suggested that while both plants can serve as immune boosters and blood tonics, there is need for caution on excessive and prolonged consumption of P. amarus.en_US
dc.identifier.citationTaiwo, I. A. Oboh, B.O. & Francis-Garuba, P. N. (2009). Haematological Properties of Aqueous Extracts of Phyllantus amarus (Schum and Thonn.) and Xylopia aethiopica (Dunal) A. Rich in Albino rats. Ethno Medicine. 3(2), 99-103en_US
dc.identifier.otherDOI: 10.1080/09735070.2009.11886345
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5192
dc.language.isoenen_US
dc.publisherKamla-Rajen_US
dc.subjectImmunostimulant, Liver Enzymes, Hepatotoxicen_US
dc.titleHaematological Properties of Aqueous Extracts of Phyllantus amarus (Schum and Thonn.) and Xylopia aethiopica (Dunal) A. Rich in Albino ratsen_US
dc.typeArticleen_US
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