Effects of practice change on outcomes of extremely preterm infants with patent ductus arteriosus

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dc.contributor.authorEzenwa, B.N
dc.contributor.authorPena, E
dc.contributor.authorSchlegel, A
dc.contributor.authorBapat, R
dc.contributor.authorShepherd, E.G
dc.contributor.authorNelin, L.D
dc.date.accessioned2019-08-26T10:01:56Z
dc.date.available2019-08-26T10:01:56Z
dc.date.issued2018
dc.descriptionStaff Publicationsen_US
dc.description.abstractAim To determine whether a decrease in patent ductus arteriosus (PDA) treatment or ligation in extremely preterm (EP) infants was associated with changes in rates of mortality and/or morbidities. Methods Observational study on EP infants admitted from 2008 to 2015. The small baby guidelines do not mandate ligation, however, in late 2010 the guidelines were amended based on new literature suggested that ligation may increase rates of morbidities. Results There were 717 EP infants admitted during the study period. There were no significant changes in gestational age, birthweight or annual admissions during the study period. The annual rate of PDA medical treatment declined significantly (R = 0.83, p = 0.01), while the annual rate of PDA ligation declined substantially (R = 0.88, p = 0.004). The annual mortality rate also declined significantly (R = 0.81, p = 0.014). The annual rates of bronchopulmonary dysplasia (BPD), necrotising enterocolitis and intraventricular haemorrhage did not change significantly. Conclusion In this cohort of EP patients, the rate of PDA ligation decreased substantially since 2010, with no apparent adverse effects on mortality or rates of BPD. These data are consistent with the concept that ligation does not improve outcomes in EP infants.en_US
dc.identifier.citationEzenwa, B. [Et...al], (2019). Effects of practice change on outcomes of extremely preterm infants with patent ductus arteriosus. Acta Paediatr, Vol.108: 88-93pp.en_US
dc.identifier.otherdoi:10.1111/apa.14423
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/4714
dc.language.isoenen_US
dc.publisherActa Paediatricaen_US
dc.subjectNeurodevelopmental outcomeen_US
dc.subjectMortalityen_US
dc.subjectBronchopulmonary dysplasiaen_US
dc.subjectPatent ductus arteriosusen_US
dc.subjectExtremely preterm (EP) infantsen_US
dc.subjectPDA ligationen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleEffects of practice change on outcomes of extremely preterm infants with patent ductus arteriosusen_US
dc.typeArticleen_US
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