Dietary Nutrients and Adinopectin rs266729 SNP (-11377C>G) Association with Blood Pressure In Nigerian Young Adults
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Osinubi, A.A. A.
Tai Solarin University of Education
Studies have shown conflicting associations between adiponectin gene and blood pressure and between intakes of selected nutrients and blood pressure. We investigated the associations of blood pressure with selected nutrients and rs266729, a single nucleotide polymorphism (SNP) in adiponectin gene using a cross-sectional study involving SNP genotyping using MassARRAY and analysis of dietary intake with standardized questionnaire, linear regression analysis was used to investigate the associations of blood pressure with rs266729 in additive genetic model and the selected nutrients after adjustment for age, sex, body mass index (BMI) and alcohol intake. A reasonably high significant correlation between systolic blood pressure (SBP) and diastolic blood pressure (DBP) was seen (correlation [r], 0.70; 95% confidence interval [CI], 0.58 - 0.79; P = 2.665e -15). However, in the adjusted model, dietary intake of calcium was inversely related to SBP (ß, -0.0124;SE, 0.0053; P =0.022) but not DBP (ß, - 0.0073; SE, 0.0037; P = 0.053). In addition, rs266729 SNP ( -11377C>G) was directly related to DBP (ß, 5.5095; SE, 2.557; P = 0.035) but not SBP (ß, 0.1147; SE, 9.351; P = 0.224). This study has not only further established that strong relationship exists between SBP and DBP but also reinforced the fact that differences between these two traits exist at the genetic and epidemiological levels.
hypertension , blood pressure , rs2666729 , Nigeria
Ogundele, O. E., Adekoya, K. O., Osinubi, A. A. A., Awofala, A. A. and Oboh, B. O. (2018). Dietary Nutrients and Adinopectin rs266729 SNP (-11377C>G) Association with Blood Pressure In Nigerian Young Adults. TASUED Journal of Pure and Applied Sciences. 1 (1) : 47 - 55.