Musanga cecropioides leaf extract exhibits anti-inflammatory and anti-nociceptive activities in animal models

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dc.contributor.authorIbrahim, M.B.
dc.contributor.authorSowemimo, A.A.
dc.contributor.authorEboji, O.
dc.contributor.authorFageyinbo, M.S.
dc.contributor.authorOlowokudejo, A.
dc.date.accessioned2020-01-15T11:39:34Z
dc.date.available2020-01-15T11:39:34Z
dc.date.issued2015
dc.descriptionStaff publicationsen_US
dc.description.abstractExtract obtained from the leaves of Musanga cecropioides R. Br. ex Tedlie, Urticaceae, a tree growing in Africa, is used traditionally in the treatment of edema and rheumatism. The anti-inflammatory and antinociceptive properties of ethanol extract were studied using the carrageenan, histamine, serotonin and xylene-induced edema tests as well as the formalin, mouse writhing and tail clip tests. Significant dose dependent inhibition was observed in the carrageenan model with peak inhibition at 150 mg/kg (71.43%, 90 min, p < 0.001). In the histamine and serotonin models, the extract caused significant inhibition of 83.33% (p < 0.05) and 45% (p < 0.01) at 120 min respectively. For the xylene model, the extract showed maximum inhibition (59.25%) at 200 mg/kg. Also, M. cecropioides produced significant anti-nociceptive activity in the mouse writhing (55.12%, p < 0.01), formalin (81.88%, p < 0.01) and tail clip (11.78%, p < 0.001) tests at 200 mg/kg respectively. The results obtained in this study demonstrated that the ethanolic leaf extract of M. cecropioides possesses anti-inflammatory effect possibly mediated via histaminergic and serotonergic inhibition and anti-nociceptive effect mediated via peripheral mechanism with mild central involvement.en_US
dc.identifier.citationSowemimo AA. Eboji O, Fageyinbo MS, Olowokudejo A, Ibrahim MB. Musanga cecropioides leaf extract exhibits anti-inflammatory and anti-nociceptive activities in animal models. Revista Brasileira de Farmacognosia 2015, 25; 506 - 512.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7400
dc.language.isoenen_US
dc.relation.ispartofseriesRevista Brasileira de Farmacognosia;Vol.25
dc.subjectAnti-nociceptiveen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectMusanga cecropioidesen_US
dc.subjectPhenolen_US
dc.subjectFlavonoiden_US
dc.subjectMineral contenten_US
dc.subjectResearch Subject Categories::PHARMACY::Pharmacognosyen_US
dc.titleMusanga cecropioides leaf extract exhibits anti-inflammatory and anti-nociceptive activities in animal modelsen_US
dc.typeArticleen_US
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