Toxicity of Aflatoxins from selected Consumables in Lagos (Nigeria)
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Date
2005
Authors
Thomas A.E.
Coker H.A.B.
Odukoya O.A.
Abdul-Kareem A.
Adepoju-Bello A.A.
Journal Title
Journal ISSN
Volume Title
Publisher
EJEAFChe
Abstract
This study quantified aflatoxin levels assessedcytotoxicity and pathological effects of pro-carcinogens extracted from consumables (groundnuts, beans) on biological systems and established data on the dose - response characteristics. HPLC analysis quantified levels of aflatoxins in the products. Brine Shrimp Lethality (BSL) assay was used for cytotoxicity while toxicity was determined by the pathological effects
of the aflatoxin extracts on the vital organs (lungs, liver and kidneys) of mice. Level of aflatoxin is more in beans than in groundnuts. Both have aflatoxin Gl in highest abundance (01in beans >groundnut). The groundnut product was more toxic on the brine shrimps while acute lethalityshowed the beans products to be more toxic than the groundnut product. Toxicity caused hydropic
degeneration of hepatocytes and severe diffuse periportal necrosis of the liver, acute tubular necrosis
manifested as patchy loss of tubular epithelium, dilation of some tubules and presence of intraluminal
casts in the kidneys and lungs showed congestion with patchy areas of haemorrhage and collapse.
Description
Scholarly articles
Keywords
Beans , Groundnuts , Aflatoxins , Vital organs , Research Subject Categories::PHARMACY::Pharmaceutical chemistry
Citation
Thomas AE, Coker HAB, Odukoya OA, Abdul-Kareem A and Adepoju-Bello AA (2005). Toxicity of Aflatoxins from selected Consumables in Lagos (Nigeria). Electron. J. Environ. Agric. Food Chem. 4(6): 1111-1116.