Toxicity of Aflatoxins from selected Consumables in Lagos (Nigeria)

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dc.contributor.authorThomas A.E.
dc.contributor.authorCoker H.A.B.
dc.contributor.authorOdukoya O.A.
dc.contributor.authorAbdul-Kareem A.
dc.contributor.authorAdepoju-Bello A.A.
dc.date.accessioned2022-01-01T22:12:40Z
dc.date.available2022-01-01T22:12:40Z
dc.date.issued2005
dc.descriptionScholarly articlesen_US
dc.description.abstractThis study quantified aflatoxin levels assessedcytotoxicity and pathological effects of pro-carcinogens extracted from consumables (groundnuts, beans) on biological systems and established data on the dose - response characteristics. HPLC analysis quantified levels of aflatoxins in the products. Brine Shrimp Lethality (BSL) assay was used for cytotoxicity while toxicity was determined by the pathological effects of the aflatoxin extracts on the vital organs (lungs, liver and kidneys) of mice. Level of aflatoxin is more in beans than in groundnuts. Both have aflatoxin Gl in highest abundance (01in beans >groundnut). The groundnut product was more toxic on the brine shrimps while acute lethalityshowed the beans products to be more toxic than the groundnut product. Toxicity caused hydropic degeneration of hepatocytes and severe diffuse periportal necrosis of the liver, acute tubular necrosis manifested as patchy loss of tubular epithelium, dilation of some tubules and presence of intraluminal casts in the kidneys and lungs showed congestion with patchy areas of haemorrhage and collapse.en_US
dc.identifier.citationThomas AE, Coker HAB, Odukoya OA, Abdul-Kareem A and Adepoju-Bello AA (2005). Toxicity of Aflatoxins from selected Consumables in Lagos (Nigeria). Electron. J. Environ. Agric. Food Chem. 4(6): 1111-1116.en_US
dc.identifier.issn579-4377
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9888
dc.language.isoenen_US
dc.publisherEJEAFCheen_US
dc.subjectBeansen_US
dc.subjectGroundnutsen_US
dc.subjectAflatoxinsen_US
dc.subjectVital organsen_US
dc.subjectResearch Subject Categories::PHARMACY::Pharmaceutical chemistryen_US
dc.titleToxicity of Aflatoxins from selected Consumables in Lagos (Nigeria)en_US
dc.typeArticleen_US
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