Genetic polymorphisms of Vascular Endothelial Growth Factor (VEGF) associated with endometriosis in Nigerian women

Simple item page
dc.contributor.authorBabah, O.A.
dc.contributor.authorOjewunmi, O.O.
dc.contributor.authorOsuntoki, A.A.
dc.contributor.authorSimon, M.A.
dc.contributor.authorAfolabi, B.B.
dc.date.accessioned2022-01-10T13:23:42Z
dc.date.available2022-01-10T13:23:42Z
dc.date.issued2021-10
dc.descriptionScholarly articlesen_US
dc.description.abstractObjective: To determine if genetic polymorphism of VEGF is associated with the development of endometriosis in Nigerian women. Study design: Case control study of 100 women (50 healthy controls and 50 with endometriosis). Serum VEGF concentration of participants were determined using enzyme-linked immunosorbent assay (ELISA) technique. Genomic DNAs were isolated from peripheral blood samples and quantified by nanodrop spectrophotometer one. Single nucleotide polymorphisms genotyping was carried out by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: Mean age of participants was 32.96 ± 6.91 years for control and 32.04 ± 7.56 years for cases. VEGF levels in case and control groups were not statistically different (82.68 pg/ml [69.11-121.11 pg/ml] vs. 82.81 pg/ml [72.90-113.82 pg/ml] respectively; p = 0.967). All four genotypes examined were in Hardy-Weinberg equilibrium. Minor allele frequency of - 460T > C, - 1154G > A, + 936C > T and + 2578C > A were 24%, 8%, 6% and 10% in the control and 19%, 9%, 5% and 14% in endometriosis patients. However, allele and genotype distributions of - 460T > C, - 1154G > A, + 936C > T and + 2578C > A VEGF polymorphisms in endometriosis patients and control were not significantly different (p > 0.05). Conclusion: Our preliminary findings revealed no association between endometriosis and - 460T > C, - 1154G > A, + 936C > T and + 2578C > A of VEGF genes among Nigerian women.en_US
dc.identifier.citationBabah OA, Ojewunmi OO, Osuntoki AA, Simon MA, Afolabi BB. Genetic polymorphisms of Vascular Endothelial Growth Factor (VEGF) associated with endometriosis in Nigerian women. Hum Genomics. 2021 Oct 30;15(1):64. doi: 10.1186/s40246-021-00364-x. PubMed PMID: 34717756; PubMed Central PMCID: PMC8556990.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10065
dc.language.isoenen_US
dc.publisherHum Genomicsen_US
dc.subjectAscitesen_US
dc.subjectEndometriosisen_US
dc.subjectGenetic polymorphismen_US
dc.subjectNigeriaen_US
dc.subjectVascular endothelial growth factoren_US
dc.subjectResearch Subject Categories::MEDICINE::Surgery::Obstetrics and women's diseases::Obstetrics and gynaecologyen_US
dc.titleGenetic polymorphisms of Vascular Endothelial Growth Factor (VEGF) associated with endometriosis in Nigerian womenen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
AFOLABI Genetic polymorphisms of Vascular Endothelial.pdf
Size:
790.61 KB
Format:
Adobe Portable Document Format
Description:
Primary research
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Obstetrics and Gynaecology- Scholarly Publications