Steady state hemoglobin concentration and packed cell volume in homozygous sickle cell disease patients in Lagos, Nigeria

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dc.contributor.authorAkinbami, A
dc.contributor.authorDosunmu, AO
dc.contributor.authorAdediran, A
dc.contributor.authorOshinaike, O
dc.contributor.authorAdebola, P
dc.contributor.authorOsunkalu, VO
dc.contributor.authorArogundade, O
dc.contributor.authorAdelekan, O
dc.date.accessioned2019-12-16T14:29:00Z
dc.date.available2019-12-16T14:29:00Z
dc.date.issued2012
dc.description.abstractBackground: Sickle cell disease is a genetic disorder of hemoglobin causing myriad of pathology including anemia. The purpose of this study was to evaluate the baseline values of steady state hemoglobin and packed cell volume as a guide to managing the early recognition of hemolytic crises in sickle cell anemia. Methods: A cross-sectional study was conducted among the sickle cell patients attending the Sickle Cell clinic of Lagos State University Teaching Hospital, Ikeja. A blood sample of 4.5 ml blood was collected from each participant for hemoglobin concentration and packed cell volume. All blood samples were also screened for HIV and hemoglobin phenotypes were done using cellulose acetate hemoglobin electrophoresis at pH 8.6. Results: A total of 98 subjects in steady state were recruited, consisting of 53 (54.1%) females and 45 (45.9%) males. The overall means were 7.92±1.49 and 24.46±4.76; a female mean of 7.73±1.45; 23.89±4.60, and a male mean of 8.14±1.54 and 25.14±4.91 were obtained for hemoglobin and packed cell volume, respectively. Sixty – nine of the 98 (70.40%) subjects have been previously transfused with blood. Conclusion: The mean hemoglobin concentration and packed cell volume in males was higher than females. The overall mean was lower than what was expected for age and sex. Over two-third of sickle cell anemia population had been transfused.en_US
dc.identifier.citationAkinsegun Akinbami, FMCPath, MPH, MSc, MBChB,*,1 Adedoy Dosunmu Adedoyin, Adewumi Adediran, Olajumoke Oshinaike, Adebola Phillip, Osunkalu Vincent, Arogundade Olanrewaju and Adelekan Oluwaseun. Steady state hemoglobin concentration and packed cell volume in homozygous sickle cell disease patients in Lagos, Nigeria. Caspian J Intern Med. 2012 Spring; 3(2): 405–409.en_US
dc.identifier.otherPMC3861903
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7112
dc.language.isoenen_US
dc.publisherCaspian Journal of Internal Medicineen_US
dc.subjectHomozygous sickle cell disease,en_US
dc.subjectSteady stateen_US
dc.subjecthemoglobin concentrationen_US
dc.subjectpacked cell volumeen_US
dc.titleSteady state hemoglobin concentration and packed cell volume in homozygous sickle cell disease patients in Lagos, Nigeriaen_US
dc.typeArticleen_US
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