Interaction between Ciprofloxacin and some metal ions.
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Date
2009
Authors
Adepoju-Bello A.A.
Coker H.A.B.
Abioye A.O.
Ayoola G.A.
Journal Title
Journal ISSN
Volume Title
Publisher
J. Pharm. Sci. & Pharmaceut. Prac.
Abstract
Purpose: Solid state synthesis of a compound is not so common. Concomitant administration of quinolones with metal ion containing drug preparations, food supplements and fruit juices have been reported to cause a reduction in the activity of quinolones.
Objective: This study was carried out to determine if there is an interaction between ciprofloxacin and the metal ions in the solid state.
Method: Divalent, Zn2+, Cu2+ and trivalent, Al3+, were used for the study. The pure ciprofloxacin (CIP)sample, triturated fluoroquinolone and metal ion in the solid state and the metal ions were analysed using FT-IR spectrophotometer.
Result: The results obtained showed a carbonyl absorption band at 1708.2 cm-1 for ciprofloxacin, which was absent on the ciprofloxacin-metal complex infrared spectrum indicating an interaction.
Conclusion: There was an interaction between ciprofloxacin and the metal ions at the solid state.
Description
Scholarly articles
Keywords
Research Subject Categories::PHARMACY , Ciprofloxacin , Solid state interaction , Ciprofloxacin- metal complex , Metal ions , Research Subject Categories::PHARMACY
Citation
Adepoju-Bello AA, Coker HAB, Abioye AO, Ayoola GA, (2009). Interaction between Ciprofloxacin and some metal ions. J. Pharm. Sci. & Pharmaceut. Prac. 9 (1): 45- 47.