Interaction between Ciprofloxacin and some metal ions.
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J. Pharm. Sci. & Pharmaceut. Prac.
Purpose: Solid state synthesis of a compound is not so common. Concomitant administration of quinolones with metal ion containing drug preparations, food supplements and fruit juices have been reported to cause a reduction in the activity of quinolones. Objective: This study was carried out to determine if there is an interaction between ciprofloxacin and the metal ions in the solid state. Method: Divalent, Zn2+, Cu2+ and trivalent, Al3+, were used for the study. The pure ciprofloxacin (CIP)sample, triturated fluoroquinolone and metal ion in the solid state and the metal ions were analysed using FT-IR spectrophotometer. Result: The results obtained showed a carbonyl absorption band at 1708.2 cm-1 for ciprofloxacin, which was absent on the ciprofloxacin-metal complex infrared spectrum indicating an interaction. Conclusion: There was an interaction between ciprofloxacin and the metal ions at the solid state.
Research Subject Categories::PHARMACY , Ciprofloxacin , Solid state interaction , Ciprofloxacin- metal complex , Metal ions , Research Subject Categories::PHARMACY
Adepoju-Bello AA, Coker HAB, Abioye AO, Ayoola GA, (2009). Interaction between Ciprofloxacin and some metal ions. J. Pharm. Sci. & Pharmaceut. Prac. 9 (1): 45- 47.