Synthesis and Antibacterial Activity of N,N-Diethyl-3-substituted-2- (4-methyl-phenylsulfonamido)alkanamides and their Arylsulfonamide Precursors
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Date
2013-03
Authors
Ajani, O.O.
Familoni, O.B.
Wu, F.
Echeme, J.O.
Sujiang, Z.
Journal Title
Journal ISSN
Volume Title
Publisher
eprints.covenantuniversity.edu.ng
Abstract
A series of N,N-diethyl-3-substituted-2-(4-methylphenylsulfonamido)alkanamides (8a-k) and their
arylsulfonamide precursors (7a-k) have been synthesized via facile approach. The chemical structures of the synthesized
compounds were confirmed by analytical data and spectroscopic means. The in vitro antibacterial screening of these
compounds along with streptomycin, showed N,N-diethyl-2-(4-methylphenylsulfonamido) -3-phenylpropanamide (8j) to be
the most active agent on Escherichia coli at MIC of 12.5 μg/mL and on Staphylococcus aureus at MIC of 25 μg/mL.
Description
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry::Organic synthesis , in vitro stability , antibacterial activity , sulphonylation , substituted amide
Citation
Ajani, O. O., Familoni, O. B., Wu, F., Echeme, J. O., & Sujiang, Z. (2013). Synthesis and Antibacterial Activity of N, N-Diethyl-3-substituted-2-(4-methyl-phenylsulfonamido) alkanamides and their Arylsulfonamide Precursors. International Journal of Drug Design and Discovery, 4(1), 983-993.