Synthesis and Antibacterial Activity of N,N-Diethyl-3-substituted-2- (4-methyl-phenylsulfonamido)alkanamides and their Arylsulfonamide Precursors

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dc.contributor.authorAjani, O.O.
dc.contributor.authorFamiloni, O.B.
dc.contributor.authorWu, F.
dc.contributor.authorEcheme, J.O.
dc.contributor.authorSujiang, Z.
dc.date.accessioned2019-09-05T09:54:03Z
dc.date.available2019-09-05T09:54:03Z
dc.date.issued2013-03
dc.description.abstractA series of N,N-diethyl-3-substituted-2-(4-methylphenylsulfonamido)alkanamides (8a-k) and their arylsulfonamide precursors (7a-k) have been synthesized via facile approach. The chemical structures of the synthesized compounds were confirmed by analytical data and spectroscopic means. The in vitro antibacterial screening of these compounds along with streptomycin, showed N,N-diethyl-2-(4-methylphenylsulfonamido) -3-phenylpropanamide (8j) to be the most active agent on Escherichia coli at MIC of 12.5 μg/mL and on Staphylococcus aureus at MIC of 25 μg/mL.en_US
dc.identifier.citationAjani, O. O., Familoni, O. B., Wu, F., Echeme, J. O., & Sujiang, Z. (2013). Synthesis and Antibacterial Activity of N, N-Diethyl-3-substituted-2-(4-methyl-phenylsulfonamido) alkanamides and their Arylsulfonamide Precursors. International Journal of Drug Design and Discovery, 4(1), 983-993.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5162
dc.language.isoen_USen_US
dc.publishereprints.covenantuniversity.edu.ngen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry::Organic synthesisen_US
dc.subjectin vitro stabilityen_US
dc.subjectantibacterial activityen_US
dc.subjectsulphonylationen_US
dc.subjectsubstituted amideen_US
dc.titleSynthesis and Antibacterial Activity of N,N-Diethyl-3-substituted-2- (4-methyl-phenylsulfonamido)alkanamides and their Arylsulfonamide Precursorsen_US
dc.typeArticleen_US
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