Genotoxic and Biochemica Effects of Consumption of Heavy Metal Contaminated Fish and Its Reversal Using Zinc Supplements in Rats

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dc.contributor.authorBolawa, O.E.
dc.contributor.authorEbuehi, O.A.T.
dc.date.accessioned2019-11-22T10:45:08Z
dc.date.available2019-11-22T10:45:08Z
dc.date.issued2017
dc.descriptionStaff publicationsen_US
dc.description.abstractIntroduction: Heavy metals such as lead, cadmium, chromium etc are environmental contaminants. They are also known today as human and animal carcinogens. Objectives: The aim of the study was to evaluate the genotoxic and biochemical effect of feeding rat with fish obtained from heavy metal contaminated water bodies in Lagos, Nigeria. Methods: DNA damage was investigated using DNA lading assay, while heavy metals and antioxidants were analyzed from fishes obtained from contaminated water bodies. Results: There was fragmentation of blood chromosomal DNA in rats fed with heavy metal contaminated fish, while in the control and zinc supplemented group, there was no fragmentation. Heavy metals were detected in the tissues and serum of exposed rat, while the activity of the serum catalase and reduced glutathione significantly decreased. Conclusion: The consumption of heavy metal contaminated fish resulted in DNA fragmentation and its deposition in the rat tissue. Zinc supplementation prevented the degradation of DNA and potentiated antioxidant activities.en_US
dc.identifier.citationBolawa O. E. & Ebuehi O. A. T. (2017). Genotoxic and Biochemica Effects of Consumption of Heavy Metal Contaminated Fish and Its Reversal Using Zinc Supplements in Rats. Journal of Biotechnology Research, Academic Research Publishing Group, vol. 3(10), pages 85-93, 10-2017.en_US
dc.identifier.issn2413-3256
dc.identifier.issn2413-8878
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6951
dc.language.isoenen_US
dc.publisherAcademic Research Publishing Groupen_US
dc.relation.ispartofseriesJournal of Biotechnology Research, Academic Research Publishing Group;Vol.3(10)
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistryen_US
dc.subjectDNAen_US
dc.subjectCatalaseen_US
dc.subjectGlutathioneen_US
dc.subjectHeavy metalsen_US
dc.subjectGenotoxicityen_US
dc.titleGenotoxic and Biochemica Effects of Consumption of Heavy Metal Contaminated Fish and Its Reversal Using Zinc Supplements in Ratsen_US
dc.typeArticleen_US
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