Chemical and biological studies on Bridelia ferruginea grown in Nigeria

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dc.contributor.authorAfolayan, M.
dc.contributor.authorSrivedavyasasri, R.
dc.contributor.authorAsekun, O.T.
dc.contributor.authorFamiloni, O.B.
dc.contributor.authorRoss, S.A.
dc.date.accessioned2019-08-26T12:48:02Z
dc.date.available2019-08-26T12:48:02Z
dc.date.issued2018
dc.description.abstractPhytochemical investigation of the methanolic extract of dried leaves of Bridelia ferruginea led to the isolation and identification of fourteen compounds (1–14): compound 1 [mixture of palmitic, stearic and oleic acids], stearyl monoester of 2-O-β-ᴅ-glucosylglycerol (2), 6β-hydroxy-(20R)-24-ethylcholest-4-en-3-one (3a), 6β-hydroxy-(20R)-24-ethylcholest-4,22-dien-3-one (3b), lutein (4), vomifoliol (5), corilagin (6), kaempferide-3-O-β-ᴅ-glucoside (7), myricetin (8), isomericitrin (9), isoquercetin (10), myricitrin (11), quercitrin (12), rutin (13), and β-sitosterol glucoside (14). The total extract exhibited moderate activity towards CB2 receptor and 90% inhibition against leishmanial pathogen Trypanosoma brucei. Compound 4 exhibited 73% displacement in CB2 receptor with IC50 56.47 μM, and 93% inhibition towards T. brucei with IC50 4.16 μM. Compound 11 showed 99% inhibition towards Escherichia coli with IC50 1.123 μM.en_US
dc.identifier.citationAfolayan, M., Srivedavyasasri, R., Asekun, O. T., Familoni, O. B., & Ross, S. A. (2019). Chemical and biological studies on Bridelia ferruginea grown in Nigeria. Natural product research, 33(2), 287-291.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/4727
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistryen_US
dc.subjectBridelia ferrugineaen_US
dc.subjectflavonoidsen_US
dc.subjectcannabinoiden_US
dc.subjectantibacterialen_US
dc.subjectantileishmanialen_US
dc.titleChemical and biological studies on Bridelia ferruginea grown in Nigeriaen_US
dc.typeArticleen_US
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