Effect of Carica papaya (Linn) aqueous leaf extract on pharmacokinetic profile of ciprofloxacin in rabbits
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Date
2017-01
Authors
Ukpo, Grace E
Owolabi, Mbang A
Imaga, Ngozi OA
Oribayo, Oluwafunke O
Ejiroghene, Akpobomen J
Journal Title
Journal ISSN
Volume Title
Publisher
Tropical Journal of Pharmaceutical Research
Abstract
Purpose: To investigate the fate of ciprofloxacin, after concomitant administration with the aqueous leaf
extract of Carica papaya, which herbal practitioners in Nigeria have found helpful in the treatment of
painful crisis in sickle cell anaemia (SCA) patients.
Method: Thirteen rabbits were fasted for 12 h and given by oral route 20 mg/kg ciprofloxacin (control
group); after a 3-week crossover period, the animals were given 500 mg/kg aqueous extract of Carica
papaya followed by 20 mg/kg ciprofloxacin (treatment group). Blood samples were collected over a
period of 0 - 24 h post-dosing, and pharmacokinetic profile of ciprofloxacin in plasma sample
determined using a validated high performance liquid chromatography (HPLC) method.
Results: Time to attain maximum plasma ciprofloxacin concentration (Tmax), lag time and clearance
(CL/F) were higher in the treated group; all other pharmacokinetic parameters showed significant
decrease in the treated group (p < 0.005) compared to the control group. The slow rate of elimination of
ciprofloxacin in the control group (0.32 ± 0.11 h-1) compared to the treated group (0.21 ± 0.07 h-1) was
not due to kidney impairment as plasma creatinine level indicated that kidney function was within normal
range (0.68 ± 2.78 mg/dl).
Conclusion: The results of the study show that there is interaction between ciprofloxacin and Carica
papaya. This interaction can be avoided by taking ciprofloxacin at least 3 h prior to administration of the
leaf extract of C. papaya.
Description
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistry , Carica papaya , Ciprofloxacin , Sickle cell anaemia , Herb-drug interaction , Pharmacokinetics
Citation
Grace E Ukpo, Mbang A Owolabi, Ngozi OA Imaga, Oluwafunke O Oribayo and Akpobomen J Ejiroghene (2017). Tropical Journal of Pharmaceutical Research January 16 (1): 127-134