A novel herbal beverage from Moringa oleifera, Dennettia tripetala, and Citrus sinensis abates Bonny light crude oil-induced oxidative injury in rat brain and liver

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dc.contributor.authorEbuehi, O.A.T.
dc.contributor.authorErukainure, OL
dc.contributor.authorRebecca Adione
dc.contributor.authorAyodeji B. Oyenihi
dc.date.accessioned2024-05-08T12:10:59Z
dc.date.available2024-05-08T12:10:59Z
dc.date.issued2018
dc.descriptionScholarly article
dc.description.abstractA novel herbal beverage (HB) was formulated from blends of Moringa oleifera, Dennettia tripetala, and Citrus sinensis and investigated for its antioxidative protective effect against Bonny light crude oil (BLCO)-induced oxidative injury in rat brain and hepatic tissues. Male albino rats were orally exposed to BLCO (800 mg/kg bodyweight) for 7 days, then treated with HB (200 and 400 mg/kg bodyweight) for another 7 days. Reduced glutathione (GSH) and malondialdehyde (MDA) levels were depleted and elevated respectively in both tissues on exposure to BLCO, which was (p < 0.05) reversed after treatment with HB. Treatment with HB led to significant (p < 0.05) increase in superoxide dismutase (SOD) activities in BLCO-exposed rats. BLCO also caused a significant increase in total bilirubin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels, while treatment with HB led to significant (p < 0.05) reduced levels. These results thus suggest an ameliorative effect of HB on BLCO-induced oxidative injury in brain and hepatic tissues, which may be attributed to the synergistic effects of the phytochemicals, with quercetin playing a major role.
dc.identifier.citationEbuehi, O.A.T., Erukainure, OL, Rebecca Adione, Ayodeji B. Oyenihi (2018). A novel herbal beverage from Moringa oleifera, Dennettia tripetala, and Citrus sinensis abates Bonny light crude oil-induced oxidative injury in rat brain and liver. Comparative Clinical Pathology.
dc.identifier.other10.1007
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/12866
dc.language.isoen
dc.publisherComparative Clinical Pathology
dc.titleA novel herbal beverage from Moringa oleifera, Dennettia tripetala, and Citrus sinensis abates Bonny light crude oil-induced oxidative injury in rat brain and liver
dc.typeArticle
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