Effect of Flabellaria paniculata Cav. extracts on gastric ulcer in rats

Simple item page
dc.contributor.authorSofidiya, M.O.
dc.contributor.authorAgufobi, L.
dc.contributor.authorAkindele, A.J.
dc.contributor.authorOlowe, J.A.
dc.contributor.authorFamiloni, O.B.
dc.date.accessioned2021-04-19T10:35:09Z
dc.date.available2021-04-19T10:35:09Z
dc.date.issued2012
dc.descriptionScholarly articlesen_US
dc.description.abstractThe leaves and root of Flabellaria paniculata (Malpighiaceae) are frequently used in the treatment of wounds and ulcers in Nigerian folk medicine. The purpose of this study was to compare the effect of ethanolic extracts from the leaves (FPL) and root (FPR) of F. paniculata on gastric ulcers in rats. Methods The effect of FPL and FPR (100, 200 and 400 mg/kg) was evaluated in ethanol and indomethacin gastric ulcer models. Control groups for FPL and FPR were orally treated with 3% Tween 20 and distilled water respectively. FPL was further investigated in pylorus ligation model. Misoprostol and cimetidine were used as reference. Results FPL significantly (P < 0.05) reduced gastric lesions by 82.22% and 67.32% in ethanol and indomethacin induced ulcer models at 100 mg/kg respectively while FPR (100, 200 and 400 mg/kg) did not exert significant effect in the two models. In pylorus ligation model, FPL exerted a significant preventive antiulcer effect as indicated by reduction in gastric volume at 200 and 400 mg/kg doses. Only 400 mg/kg of the extract exerted a significant reduction in ulcer index when compared with the control group. The oral route LD50 of FPL was estimated to be 4570 mg/kg while that of FPR was 2754 mg/kg. The LD50 in intraperitoneal injection was estimated to be 1202.26 and 1380.38 mg/kg for FPL and FPR respectively. The phytochemical investigation showed that both extracts possess triterpenoids and saponin, while the presence of flavonoid was detected only in FPL. Conclusions The results of this study indicated that FPL and not FPR is effective against experimentally induced gastric ulcers. The presence of varied phytochemical constituents probably influenced the pharmacological differences between the two extracts.en_US
dc.identifier.citationMargaret O. Sofidiya, Lilian Agufobi, Abidemi J. Akindele, Johnson A. Olowe, Oluwole B. Familoni (2012). Effect of Flabellaria paniculata Cav. extracts on gastric ulcer in rats. BMC Complementary and Alternative Medicine 12,168.en_US
dc.identifier.issn14726882
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9323
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.subjectFlabellaria paniculata Caven_US
dc.subjectMalphighiaceaeen_US
dc.subjectAcute toxicityen_US
dc.subjectEthanol-induced ulceren_US
dc.subjectResearch Subject Categories::PHARMACY::Pharmacognosyen_US
dc.titleEffect of Flabellaria paniculata Cav. extracts on gastric ulcer in ratsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
22. Flabellaria antiulcer.pdf
Size:
183.65 KB
Format:
Adobe Portable Document Format
Description:
Main Article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Pharmacognosy- Scholarly Publications