Invasive candidiasis in a neonatal intensive care unit in Lagos, Nigeria.

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dc.contributor.authorEzenwa, B.N.
dc.contributor.authorOladele, R.O.
dc.contributor.authorAkintan, P.E.
dc.contributor.authorFajolu, I.B.
dc.contributor.authorOshun, P.O.
dc.contributor.authorOduyebo, O.O.
dc.contributor.authorEzeaka, V.C.
dc.date.accessioned2019-11-02T14:46:35Z
dc.date.available2019-11-02T14:46:35Z
dc.date.issued2017
dc.description.abstractBACKGROUND: Invasive candidiasis has been identified globally as a major cause of morbidity and mortality in neonatal intensive care units (NICU). Systemic candidiasis presents like bacterial sepsis and can involve multiple organs. OBJECTIVE: The objective of this study was to determine the prevalence of Candida infection in a NICU at a tertiary hospital in Nigeria and to identify its associated risk factors. MATERIALS AND METHODS: The study was a retrospective descriptive study of all cases of culture-proven invasive Candida infection (ICI) in neonates admitted to the NICU over a 4-year period. The study participants were identified from microbiology records of all neonates with a positive Candida culture. Medical records of identified neonates were also reviewed, and relevant information obtained. RESULTS: Over the 4 years, 2712 newborns were admitted to the NICU. From these, 1182 various clinical samples were collected from babies with features of sepsis and processed in the medical microbiology laboratory. Twenty-seven (2.3%) of the cultures yielded Candida organisms; fifteen of the Candida cultures were from male infants with a male:female ratio of 1.3:1. Bloodstream infection was the most frequent ICI seen in preterm babies (seven [58.3%] out of 12 babies with ICI). Nearly, all (91.7%) affected preterm infants with ICI were <1500 g in weight. All were exposed to invasive procedures and broad-spectrum antibiotics. The case fatality rate among those with ICI was 18.5%. CONCLUSION: There was a significant prevalence of invasive candidiasis in high-risk newborns and the incidence increases with increased practices in risk factors such as invasive procedures and antibiotic use and lower gestational age babies with very low birth weight.en_US
dc.identifier.citationEzenwa BN, Oladele RO, Akintan PE, Fajolu IB, Oshun PO, Oduyebo OO, Ezeaka VC. Invasive candidiasis in a neonatal intensive care unit in Lagos, Nigeria. Niger Postgrad Med J. 2017 Jul-Sep;24(3):150-154.en_US
dc.identifier.otherdoi: 10.4103/npmj.npmj_104_17
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6678
dc.language.isoenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.subjectInvasive candidiasisen_US
dc.subjectNeonatal intensive care uniten_US
dc.subjectNigeriaen_US
dc.titleInvasive candidiasis in a neonatal intensive care unit in Lagos, Nigeria.en_US
dc.typeArticleen_US
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