Antisickling and toxicological profiles of leaf and stem of Parquetina nigrescens L.

Simple item page
dc.contributor.authorImaga, N.O.A.
dc.contributor.authorGbenle, G.O.
dc.contributor.authorOkochi, V.I.
dc.contributor.authorAdenekan, S.O.
dc.contributor.authorEdeoghon, S.O.
dc.contributor.authorKehinde, M.O.
dc.contributor.authorBamiro, S.B.
dc.contributor.authorAjiboye, A.
dc.contributor.authorObinna, A.
dc.date.accessioned2019-09-20T15:02:15Z
dc.date.available2019-09-20T15:02:15Z
dc.date.issued2010-04-18
dc.description.abstractFolk medicine reportedly uses Parquetina nigrescens L. (Asclepiadaceae) as a herbal remedy for the management of sickle cell anemia. This study was carried out to screen the leaves and stem of P. nigrescens for antisickling activity, erythrocyte membrane -stabilizing effects and any end organ toxicity. Percentage reversal and inhibition of sickling parameters were analyzed on pre-sickled HbSS blood cell suspensions using sodium metabisulphite solution as inducer and 5 mg/ml parahydroxybenzoic acid and normal saline as positive and negative controls respectively. Effects of the plant extracts on the erythrocyte were assessed using osmotic fragility and the toxicity profile done via LD50 and sub-acute toxicity studies on graded concentrations of extract. Results show that P. nigrescens has appreciable antisickling activity, has no toxic effect when administered at low concentrations and protects the integrity of the erythrocyte membrane as evidenced in the fragiliogram by the reduction in hemolysis of the Hbss cells.en_US
dc.identifier.citationN. O. A. Imaga, G. O. Gbenle, V. I. Okochi, S.O. Adenekan, S. O. Edeoghon, M. O. Kehinde, S. B. Bamiro., A. Ajiboye and A. Obinna J. of Medicinal Plants Research. 4(8) 639-643. 2010en_US
dc.identifier.issn1996-0875
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5882
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistryen_US
dc.subjectAntisickling activityen_US
dc.subjectmembrane integrityen_US
dc.subjectosmotic fragilityen_US
dc.subjectParquetina nigrescensen_US
dc.subjectsickle cell diseaseen_US
dc.titleAntisickling and toxicological profiles of leaf and stem of Parquetina nigrescens L.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2_Imaga et al PARQUETINA 2010.pdf
Size:
65.02 KB
Format:
Adobe Portable Document Format
Description:
Full Text
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Biochemistry-Scholarly Publications