Toxicological Effect of Ethanolic Extract of Cannabis sativa on Brain Serotonin in Adult Wistar Rats
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Date
2016-09
Authors
Solanke, Adebayo Solomon
Ebuehi, Osaretin Albert T.
Adetona, Mutiat Olutope
Journal Title
Journal ISSN
Volume Title
Publisher
Scientific & Academic Publishing
Abstract
Studies have identified that Cannabis sativa (Marijuana) has been used recreationally and medicinally, this has
resulted in an increase in the consumption of Cannabis sativa among young people. The aim of this study is to produce data
on toxicological effect of ethanolic extract of Cannabis sativa on serotonin concentration and tissue histopathology in the
brain of adult wistar rats. Rats were divided into 3 groups with each group consisting of 8 rats. Treated groups received
ethanolic extract of Cannabis sativa 25mg/kg body weight and 10% ethanol. The treatments were administered orally within
two weeks for short duration and five weeks for long duration. The brain tissues were used for histological assay; the brain
serotonin level was determined. Results showed a significant alteration in the level of brain serotonin at two and five weeks
administration compared to the control group. Histopathological alterations were also observed.
Description
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistry , Cannabis sativa , Ethanol , Brain and serotonin
Citation
Adebayo, Solanke & Ebuehi, Osaretin & Olutope, Adetona. (2016). Toxicological Effect of Ethanolic Extract of Cannabis sativa on Brain Serotonin in Adult Wistar Rats. 2016. 97-99. 10.5923/j.ajb.20160604.02.