Short-Term Feeding of Fibre-Enriched Biscuits: Protective Effect against Hepatotoxicity in Diabetic Rats
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Date
2015
Authors
Erukainure, O.L.
Ebuehi, O.A.T.
Adeboyejo, F.O.
Oladunmoye, O.O.
Aliyu, M
Obode, O.C.
Olasehinde, T.
Elemo, G.N.
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi Publishing Corporation
Abstract
The effects of fibre-enriched biscuit on biomarkers associated with hepatotoxicity in diabetic rats were investigated. Diabetes was
induced by single intraperitoneal injection of alloxan monohydrate. Treatment lasted for 14 days after which the rats were sacrificed
by cervical dislocation. Blood serumwas analyzed to determine hepatic function enzymes.Theliver was also analyzed to determine
hepatic lipid profile and antioxidant enzymes. Induction of diabetes led to elevated levels of ALP, AST, andALT.Thesewere, however,
significantly (𝑝 < 0.05) reduced in the fibre-enriched biscuit fed (treated) group.There was no significant difference in the serum
bilirubin and total protein levels of the studied groups. Reduced albumin level was observed in the diabetic group; this was further
lowered on feeding with fibre-enriched biscuits. Induction of diabetes led to increased hepatic level of cholesterol, triglyceride
(TG), low density lipoprotein (LDL), and lipid peroxidation and decreased activities of glutathione (GSH), catalase (CAT), and
superoxide dismutase (SOD) and HDL level. These were significantly (𝑝 < 0.05) reversed on feeding with fibre-enriched biscuit.
This study portrays the protective effect of fibre-enriched biscuit on increased oxidative stress and hyperlipidemia in hepatic tissues
of alloxan-induced diabetic rats.
Description
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistry , fibre-enriched , biscuits
Citation
Erukainure, Ochuko & Ebuehi, Osaretin & Adeboyejo, Folasade & Oladunmoye, Olufunmilola & Muhammad, Aliyu & Obode, Okukwe & Olasehinde, Tosin & Elemo, Gloria. (2015). Short-Term Feeding of Fibre-Enriched Biscuits: Protective Effect against Hepatotoxicity in Diabetic Rats. Biochemistry Research International. 2015. 6. 10.1155/2015/868937.