Correlation of cardiac troponin T level, clinical parameters and myocardial ischaemia in perinatal asphyxia
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Paediatric Association of Nigeria
Introduction: Resource limitation in developing countries may preclude access to cardiac troponin-T assay thereby necessitating reliance on clinical judgment for identification of hypoxic myocardial cellular injury. Objectives: To relate selected clinical signs with elevated serum cardiac troponin-T in asphyxiated term neonates. Methods: Asphyxia was identified by low umbilical arterial blood pH . 7.20 and low five minute Apgar score . 6 while controls were term, non.asphyxiated neonates. All babies were examined for heart rate, heart rhythm irregularities, peripheral pulse volume, respiratory rate, pallor, cyanosis, heart murmur and sensorium. Results: Thirty term, asphyxiated neonates and their matched controls were studied. Central cyanosis, reduced pulse volume, pallor, depressed sensorium; tachycardia and tachypnea were all associated with increased odds ratios for abnormal cardiac troponin.T levels. Conclusion: Clinicians working in resource.limited health facilities should have a high index of suspicion for myocardial cellular injury when these signs are elicited.
neonates , asphyxia , troponin-T , myocardial injury , Research Subject Categories::MEDICINE
Uzodimma CC, Okoromah CAN, Ekure E, Ezeaka CV, Njokanma FO. Correlation of cardiac troponin T level, clinical parameters and myocardial ischaemia in perinatal asphyxia. Niger J Paed 2013; 40 (2): 112-118.