Calcium antagonists modulate oxidative stress and acrosomal reaction in rat spermatozoa

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dc.contributor.authorMorakinyo, AO
dc.contributor.authorIranloye, BO
dc.contributor.authorAdegoke, OA
dc.date.accessioned2019-08-30T08:45:17Z
dc.date.available2019-08-30T08:45:17Z
dc.date.issued2011
dc.description.abstractIntroduction: Calcium ions are vital in many biological processes and qualify as an almost ubiquitous intracellular second messenger. This indicates the multiplicity of the effects associated with drug actions aimed at interfering with calcium ions. To examine the cellular process involved in the induction of infertility in males by calcium antagonist (CA) even in the presence of normal semen parameters, we studied the effects of different CA namely; nifedipine, verapamil and diltiazem on oxidative balance and acrosome reaction in the sperm. Material and methods: For this purpose, lipid peroxidation, antioxidants such as superoxide dismutase, catalase and reduced glutathione, and acrosomal reaction were determined in sperm samples of rats. Results: Calcium antagonist causes significant oxidative stress in the epididymal sperm with increased malondialdehyde level and a concomitant decrease in antioxidant activities of catalase and superoxide dismutase. The percentage value of acrosomal-reacted sperm in the nifedipine, verapamil and diltiazemtreated rats were 41 ±2.45, 39 ±2.92 and 42 ±1.22 respectively, compared with the control group value of 86 ±2.92. Conclusions: It appears CA oxidatively modify the sperm resulting in functional inhibition of acrosomal reaction. Suppression of the sperm acrosomal reaction is known to have serious adverse implications for fertilization.en_US
dc.identifier.citationMorakinyo AO, Iranloye BO and Adegoke OA. (2011) Calcium antagonists modulate oxidative stress and acrosomal reaction in rat spermatozoa. Arch. Med. Sci. 7: 613-618en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/4909
dc.subjectCalcium antagonisten_US
dc.subjectacrosomal reactionen_US
dc.subjectlipid peroxidationen_US
dc.subjectreactive oxygen speciesen_US
dc.subjectspermen_US
dc.titleCalcium antagonists modulate oxidative stress and acrosomal reaction in rat spermatozoaen_US
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