Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria

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Afolayan, M.
Srivedavyasasri, R.
Asekun, O.T.
Familoni, O.B.
Orishadipe, A.
Zulfiqar, F.
Ibrahim, M.A.
Ross, S.A.
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Piliostigma thonningii (Schumach.) Milne-Redhead. (Leguminosae) is used for various medicinal purposes in African countries. Phytochemical investigation of P. thonningii yielded two compounds newly isolated from natural sources, 2β-methoxyclovan-9α-ol (1), and methyl-ent-3β-hydroxylabd-8(17)-en-15-oate (2), along with 14 known compounds (3–16). Compounds 1 and 4 (alepterolic acid) showed potential selectivity towards Trypanosoma brucei brucei with IC50 7.89 and 3.42 μM, respectively. Compound 2 showed activity towards T. brucei and Leishmania donovani Amastigote with IC50 3.84 and 7.82 μM, respectively. The structure activity relationship (SAR) of the isolated metabolites suggested that hydroxylation at C-2 enhances the antiprotozoal activity towards T. brucei in sesquiterpenes 1 and 3. Similarly hydroxylation at C-3 in labdane diterpenes elevates the antiprotozoal activity towards T. brucei.
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Research Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry , Piliostigma thonningii , Sesquiterpene , diterpene , Trypanosoma brucei
Afolayan, M., (2018). Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria. Medicinal Chemistry Research, 27(10), 2325-2330.