Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria

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dc.contributor.authorAfolayan, M.
dc.contributor.authorSrivedavyasasri, R.
dc.contributor.authorAsekun, O.T.
dc.contributor.authorFamiloni, O.B.
dc.contributor.authorOrishadipe, A.
dc.contributor.authorZulfiqar, F.
dc.contributor.authorIbrahim, M.A.
dc.contributor.authorRoss, S.A.
dc.date.accessioned2019-08-28T11:53:41Z
dc.date.available2019-08-28T11:53:41Z
dc.date.issued2018-08-17
dc.descriptionStaff Publicationsen_US
dc.description.abstractPiliostigma thonningii (Schumach.) Milne-Redhead. (Leguminosae) is used for various medicinal purposes in African countries. Phytochemical investigation of P. thonningii yielded two compounds newly isolated from natural sources, 2β-methoxyclovan-9α-ol (1), and methyl-ent-3β-hydroxylabd-8(17)-en-15-oate (2), along with 14 known compounds (3–16). Compounds 1 and 4 (alepterolic acid) showed potential selectivity towards Trypanosoma brucei brucei with IC50 7.89 and 3.42 μM, respectively. Compound 2 showed activity towards T. brucei and Leishmania donovani Amastigote with IC50 3.84 and 7.82 μM, respectively. The structure activity relationship (SAR) of the isolated metabolites suggested that hydroxylation at C-2 enhances the antiprotozoal activity towards T. brucei in sesquiterpenes 1 and 3. Similarly hydroxylation at C-3 in labdane diterpenes elevates the antiprotozoal activity towards T. brucei.en_US
dc.identifier.citationAfolayan, M., (2018). Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria. Medicinal Chemistry Research, 27(10), 2325-2330.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/4828
dc.language.isoenen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistryen_US
dc.subjectPiliostigma thonningiien_US
dc.subjectSesquiterpeneen_US
dc.subjectditerpeneen_US
dc.subjectTrypanosoma bruceien_US
dc.titlePhytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeriaen_US
dc.typeArticleen_US
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