Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria
dc.contributor.author | Afolayan, M. | |
dc.contributor.author | Srivedavyasasri, R. | |
dc.contributor.author | Asekun, O.T. | |
dc.contributor.author | Familoni, O.B. | |
dc.contributor.author | Orishadipe, A. | |
dc.contributor.author | Zulfiqar, F. | |
dc.contributor.author | Ibrahim, M.A. | |
dc.contributor.author | Ross, S.A. | |
dc.date.accessioned | 2019-08-28T11:53:41Z | |
dc.date.available | 2019-08-28T11:53:41Z | |
dc.date.issued | 2018-08-17 | |
dc.description | Staff Publications | en_US |
dc.description.abstract | Piliostigma thonningii (Schumach.) Milne-Redhead. (Leguminosae) is used for various medicinal purposes in African countries. Phytochemical investigation of P. thonningii yielded two compounds newly isolated from natural sources, 2β-methoxyclovan-9α-ol (1), and methyl-ent-3β-hydroxylabd-8(17)-en-15-oate (2), along with 14 known compounds (3–16). Compounds 1 and 4 (alepterolic acid) showed potential selectivity towards Trypanosoma brucei brucei with IC50 7.89 and 3.42 μM, respectively. Compound 2 showed activity towards T. brucei and Leishmania donovani Amastigote with IC50 3.84 and 7.82 μM, respectively. The structure activity relationship (SAR) of the isolated metabolites suggested that hydroxylation at C-2 enhances the antiprotozoal activity towards T. brucei in sesquiterpenes 1 and 3. Similarly hydroxylation at C-3 in labdane diterpenes elevates the antiprotozoal activity towards T. brucei. | en_US |
dc.identifier.citation | Afolayan, M., (2018). Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria. Medicinal Chemistry Research, 27(10), 2325-2330. | en_US |
dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/4828 | |
dc.language.iso | en | en_US |
dc.subject | Research Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry | en_US |
dc.subject | Piliostigma thonningii | en_US |
dc.subject | Sesquiterpene | en_US |
dc.subject | diterpene | en_US |
dc.subject | Trypanosoma brucei | en_US |
dc.title | Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria | en_US |
dc.type | Article | en_US |
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