Chronic Angiotensin II Treatment potentiates HR slowing in Sprague-Dawley Rat during Acute Behavioral Stress

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dc.contributor.authorSpeakman, R.O
dc.contributor.authorBrown, D.R.
dc.contributor.authorCassis, L.A.
dc.contributor.authorSilcox, D.L.
dc.contributor.authorAnigbogu, C. N.
dc.contributor.authorRandall, D.C.
dc.contributor.authorHoyt, R.E.
dc.date.accessioned2019-10-07T08:37:46Z
dc.date.available2019-10-07T08:37:46Z
dc.date.issued2013
dc.descriptionStaff publicationsen_US
dc.description.abstractThis study examined the effect of2-week infusion of angiotensin-II(Ang-II; 175 ng/kg/min)via minipump in rats (n=7) upon the mean arterial blood pressure (mBP) and heart rate (HR) response to an acute stress as compared to rats infused with saline (n=7).The acute stress was produced by a classical aversive conditioning paradigm: a 15 s tone (CS+) followed by a half second tail shock. Baseline mBP in Ang-II infused rats (167.7±21.3 mm Hg; mean±SD) significantly exceeded that of controls (127.6±13.5 mm Hg). Conversely, baseline HR in the Ang-II infused rats (348±33) was significantly lower than controls (384±19 bpm). The magnitudeofthemBPincreaseduringCS+didnotdifferbetweengroups,buttheHRslowingduringCS+in the Ang-II infused rats (−13.2±8.9 bpm) was significantly greater than that seen in controls (−4.2± 5.5 bpm). This augmented bradycardia may be inferentially attributed to an accentuated increase in cardiac parasympathetic activity during CS+ in the Ang-II infused rats. The mBP increased above baseline immediately post-shock delivery in controls, but fell in the Ang-II infused rats, perhaps because of a ‘ceiling effect’ in total vascular resistance. This classical conditioning model of ‘acute stress’ differs from most stress paradigms in rats in yielding a HR slowing concomitant with a pressor response, and this slowing is potentiated by Ang-II.en_US
dc.identifier.citationHoyt, R.E. [Et...al] (2013). Chronic Angiotensin II Treatment potentiates HR slowing in Sprague-Dawley Rat during Acute Behavioral Stress. Autonomic neuroscience: Basic and Clinical 174 (1-2), 42-46.en_US
dc.identifier.otherdoi:10.1016/j.autneu.2012.12.004
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6264
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.subjectClassical pavlovian conditioningen_US
dc.subjectAnxietyen_US
dc.subjectHypertensionen_US
dc.subjectRenin angiotensin systemen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleChronic Angiotensin II Treatment potentiates HR slowing in Sprague-Dawley Rat during Acute Behavioral Stressen_US
dc.typeArticleen_US
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