Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats

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dc.contributor.authorMorakinyo, AO
dc.contributor.authorSamuel, TA
dc.contributor.authorAdekunbi, DA
dc.date.accessioned2019-08-31T11:15:19Z
dc.date.available2019-08-31T11:15:19Z
dc.date.issued2018
dc.description.abstractObjective. We investigated the eff ects of magnesium supplementation on glucose tolerance, insulin sensitivity, oxidative stress as well as the concentration of insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide induced type-2 diabetic (T2D) rats. Methods. Rats were divided into four groups designated as: 1) control (CTR); 2) diabetic untreated (DU); 3) diabetic treated with 1 mg of Mg/kg diet (Mg1-D); and 4) diabetic treated with 2 mg of Mg/kg diet (Mg2-D). T2D was induced with a single intraperitoneal (i.p.) injection of freshly prepared streptozotocin (55 mg/kg) aft er an initial i.p. injection of nicotinamide (120 mg/kg). Glucose tolerance, insulin sensitivity, lipid profile, malondialdehyde (MAD) and glutathione content, insulin receptors (INSR) and glucose transporter-4 (GLUT4), fasting insulin and glucose levels were measured, and insulin resistance index was calculated using the homeostatic model assessment of insulin resistance (HOMA-IR). Results. Magnesium supplementation improved glucose tolerance and lowered blood glucose levels almost to the normal range. We also recorded a noticeable increase in insulin sensitivity in Mg-D groups when compared with DU rats. Lipid perturbations associated T2D were significantly attenuated by magnesium supplementation. Fasting glucose level was comparable to control values in the Mg-D groups while the HOMA-IR index was signifi cantly lower compared with the DU rats. Magnesium reduced MDA but increased glutathione concentrations compared with DU group. Moreover, INSR and GLUT4 levels were elevated following magnesium supplementation in T2D rats. Conclusion. These findings demonstrate that magnesium may mediate eff ective metabolic control by stimulating the antioxidant defense, and increased levels of INSR and GLUT4 in diabetic rats.en_US
dc.identifier.citationMorakinyo AO, Samuel TA, Adekunbi DA. (2018) Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats. Endocrine Regulations 52(1): 6-16en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/4976
dc.subjectInsulin receptoren_US
dc.subjectGlucose transporter-4en_US
dc.subjectMagnesiumen_US
dc.subjectInsulinen_US
dc.subjectGlucoseen_US
dc.subjectType-2 diabetes mellitusen_US
dc.subjectMetabolismen_US
dc.titleMagnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic ratsen_US
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