Synthesis and biological properties of N2O2 Schiff bases derived from o-phenylenediamine and substituted salicylaldehydes
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Date
2014
Authors
Fasina, T.M.
Ogundele, O.O.
Ayeni, I.
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of chemical and pharmaceutical research
Abstract
Three symmetrical and two unsymmetrical N2O2 Schiff bases obtained from the condensation of o-phenylenediamine
with various salicylaldehydes namely salicylaldehyde, 5-nitrosalicylaldehyde and 5-bromosalicylaldehyde were
synthesized and characterized based on elemental analysis, IR, 1H NMR and electronic absorption spectroscopy.
The antimicrobial activity of the compounds tested against the microorganisms E. coli (ATCC 25922), E. feacalis
(ATCC 29212) and S. aureus (ATCC 25923) using the agar ditch method showed a dependence on the substituent
present in order H>NO2>Br. The unsymmetrical compounds exhibited higher activity compared to the symmetrical
compounds.
Description
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Inorganic chemistry , o-phenylenediamine , symmetrical , Schiff base , antimicrobial activity , unsymmetrica
Citation
Fasina, T. M., Ogundele, O. O., & Ayeni, I. (2014). Synthesis and biological properties of N2O2 Schiff bases derived from o-phenylenediamine and substituted salicylaldehydes. J. Chem. Pharm. Res, 6, 816-819.