Oxidative Stress in Alloxan – Induced Diabetes in Female and Male Rats.

Simple item page
dc.contributor.authorEbuehi, O.A.T.
dc.date.accessioned2022-08-30T21:15:36Z
dc.date.available2022-08-30T21:15:36Z
dc.date.issued2010
dc.description.abstractOxidative stress in alloxan-induced diabetes in female and male rats was investigated. Forty male (165±8.46g) and female (162.7±7.94g) albino Sprague Dawley rats were used for the study. The rats were injected intraperitoneally with a single dose of 150mg/body weight of alloxan monohydrate, to induce diabetes for 14 days. The rats were divided into four groups, consisting of 10 diabetic male, 10 non-diabetic male, 10 diabetic female and 10 non-diabetic female. The body weight and feed intake of the rats were fed rat chow and water ad libitum for 14 days and then sacrificed by decapitation. Blood was taken by cardiac puncture, while liver and kidney were quickly excised. The catalase activities, lipid peroxidation, glucose protein, cholesterol and triglyceride concentrations in the liver and kidney of rats were determined. Rats administered alloxan monohydrate had elevated plasma glucose levels. The body weights of diabetic female and male rats were significantly reduced compared to the non-diabetic rats. The catalase activities in liver and kidney of diabetic male or female rats were significantly lower than in non-diabetic rats but the reduction was more pronounced in diabetic female rats. The liver lipid peroxidation, cholesterol and triglyceride levels were significantly higher in the diabetic male or female than in the non-diabetic rats, but with no significant differences in the diabetic female or male rats. Data of the study indicate that sex differences do not significantly affect oxidative stress in alloxan-induced diabetes.en_US
dc.identifier.citationO. A. T. Ebuehi, A. E. Ajuluchukwu, O. T. Afolabi and A. I. Akinwande. Department of Biochemistry, College of Medicine, University of Lagos, P. M. B. 12003, Lagos, Nigeria.en_US
dc.identifier.issn1995-0764
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/11150
dc.language.isoen_USen_US
dc.publisherAmerican-Eurasian Network for Scientific Informationen_US
dc.subjectOxidative stress, alloxan –induced diabetes, catalase, lipid peroxidation, cholesterol, triglyceride, female, male ratsen_US
dc.titleOxidative Stress in Alloxan – Induced Diabetes in Female and Male Rats.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Oxidative Stress in Alloxan – Induced Diabetes in Female and Male Rats..pdf
Size:
46.66 KB
Format:
Adobe Portable Document Format
Description:
Main Article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Biochemistry-Scholarly Publications