In vitro equivalence studies of generic metformin hydrochloride tablets and propranolol hydrochloride tablets under biowaiver conditions in Lagos State, Nigeria
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Date
2012-11
Authors
Akinleye, M.O.
Oyetunde, O.O.
Tayo, F.
Aina, B.A.
Journal Title
Journal ISSN
Volume Title
Publisher
Dissolution Technologies
Abstract
This study used biowaiver conditions to assess bioequivalence of some generic products used in Nigeria. None of the generic samples tested met biowaiver conditions; therefore, in vivo bioequivalence studies are required to ascertain therapeutic
equivalence. To take advantage of the cost savings of using in vitro dissolution as a surrogate for bioequivalence studies,
manufacturers of generic products need to consider factors that affect solubility and permeability of their products when
formulating them.
Description
Staff publications
Keywords
Biowaiver , in-vitro dissolution , Metformin , propranolol , Research Subject Categories::NATURAL SCIENCES::Chemistry
Citation
Akinleye, M.O., Oyetunde, O.O., Tayo, F. and Aina, B.A. (2012). In vitro equivalence studies of generic metformin hydrochloride tablets and propranolol hydrochloride tablets under biowaiver conditions in Lagos State, Nigeria.