Iridoid Glycoside from the Leaves of Clerodendrum volubile Beauv. Shows Potent Antioxidant Activity Against Oxidative Stress in Rat Brain and Hepatic Tissues

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dc.contributor.authorEbuehi, O.A.T.
dc.date.accessioned2022-08-30T20:12:40Z
dc.date.available2022-08-30T20:12:40Z
dc.date.issued2013-09-10
dc.description.abstractABSTRACT. Aim: This study aims at reporting the isolation, structure elucidation, and antioxidant potentials of ajugoside from C. volubile leaves in sodium nitroprusside (SNP)-induced oxidative stressed rat brain and hepatic tissues. Materials and Method: An iridoid monoterpene, ajugoside was isolated from the n-butanol fraction of C. volubile and evaluated for its antioxidant protective potential on brain and liver tissues of male Wister rats in an ex vivo model. Two molar concentrations (6.4 × 10−4 M and 1.28 × 10−3 M) of the metabolite and SNP were incubated with the tissues homogenate at 37◦C for 2 hr prior to the test and assayed for catalase, superoxide dismutase (SOD) activities, and lipid peroxidation. α tocopherol (6.4 × 10−4 M) was used as standard. Results: Both molar concentrations exhibited high catalase activity in the tissues. How ever, 6.4 × 10−4 M ajugoside exhibited a very high SOD activity (liver: 96.45 and brain: 96.30%) and inhibition of lipid peroxidation (liver: 88.11 and brain: 93.27%) compared to the standard. 1.28 × 10−3 M ajugoside also exhibited good activities but lower than that of the standard and 6.4 × 10−4 M ajugoside. Discussion and Conclusion: Ajugoside showed potent antioxidant activities as evidenced by the synergistic high activities of SOD and catalase as well as inhibition of lipid peroxidation in the studied tissues.en_US
dc.identifier.citationOchuko L. Erukainure, Osaretin A.T. Ebuehi, Iqbal M. Choudhary, Achyut Adhikari, Rahman M. Hafizur, Shahida Perveen, Aliyu Muhammad, & Gloria N. Elemoen_US
dc.identifier.issnDOI: 10.3109/19390211.2013.859213
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/11136
dc.language.isoen_USen_US
dc.publisherJournal of Dietary Supplementsen_US
dc.subjectAjugoside, antioxidant, ex vivo, oxidative stressen_US
dc.titleIridoid Glycoside from the Leaves of Clerodendrum volubile Beauv. Shows Potent Antioxidant Activity Against Oxidative Stress in Rat Brain and Hepatic Tissuesen_US
dc.typeArticleen_US
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