Impaired Appropriateness of Erythropoietin in Anaemic HIV Infected Patients

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dc.contributor.authorOlu-Taiwo, A
dc.contributor.authorAmusu, A.O
dc.contributor.authorOlatunya, O.S
dc.contributor.authorAdediran, A
dc.contributor.authorAjayi, E.A
dc.contributor.authorOgbenna, A.A
dc.contributor.authorAkanmu, A.S
dc.date.accessioned2022-07-28T11:50:22Z
dc.date.available2022-07-28T11:50:22Z
dc.date.issued2016
dc.descriptionScholarly articleen_US
dc.description.abstractThis study was carried out to determine the degree of erythropoietin response in anaemic HIV infected persons. Methods: A total of 120 subjects were studied. These comprised of the study group made up of 40 HIV infected treatment naive patients who had anaemia with Haemoglobin level <10g/dL and 80 control subjects who were age and sex matched. The controls consisted of 20 HIV infected non￾anaemic individuals, 40 non-HIV infected anaemic individuals, and 20 non-HIV infected non￾anaemic individuals. Blood samples were collected for haemoglobin estimation, white cell count and platelet count by automated counter. The CD4+ cell count was done by semi-automated flow cytometer. The viral load was quantitated using PCR- based diagnostic tests and serum erythropoietin level was estimated using ELISA technique. All patients gave written informed consent with ethical approval by the hospital ethics and research committee. Results: The study groups consisted of 40 males and 80 females. The mean age of male HIV anaemic subjects (45.15±5.63, N=13) was significantly higher than that of the female HIV anaemic subjects (34.16±7.21, N=25) p=0.005. The mean CD4+ cell count of HIV non-anaemic subjects (530.55 cells/µL ±423.35) was significantly higher than HIV anaemic subjects (188.18 cells/µL ±157.09) (p=0.0009). Using regression equation the expected serum erythropoietin values for a given haemoglobin level in HIV subjects was estimated. The appropriateness of erythropoietin level was then determined and a ratio of <0.8 was considered inappropriate. Seventy one percent of the HIV anaemic subjects had erythropoietin response ratio less than 0.8. Conclusion: There was a blunted erythropoietin response for the degree of anaemia in HIV compared with HIV negative subjects.en_US
dc.identifier.citationOlu-Taiwo, A., Amusu, A.O., Olatunya, O.S., Adediran, A., Ajayi, E.A., Ogbenna, A.A. and Akanmu, A.S. (2016). Impaired Appropriateness of Erythropoietin in Anaemic HIV Infected Patients. International Blood Research and Reviews, 6(10, 1-8.en_US
dc.identifier.issn2321–7219
dc.identifier.other10.9734/IBRR/2016/26793
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10925
dc.language.isoenen_US
dc.publisherInternational Blood Research and Reviewsen_US
dc.relation.ispartofseries;IBBR.26793
dc.subjectAnaemiaen_US
dc.subjectHIVen_US
dc.subjecttreatment naïveen_US
dc.subjecterythropoietin responseen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleImpaired Appropriateness of Erythropoietin in Anaemic HIV Infected Patientsen_US
dc.typeArticleen_US
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