Chloroquine reduces blood pressure and forearm vascular resistance and increases forearm blood flow in healthy young adults.

Simple item page
dc.contributor.authorAnigbogu, C.N.
dc.contributor.authorAdigun, S.A.
dc.contributor.authorAdegunloye, B.J.
dc.contributor.authorIdong, I.
dc.date.accessioned2019-10-04T13:31:21Z
dc.date.available2019-10-04T13:31:21Z
dc.date.issued1993
dc.descriptionStaff publicationsen_US
dc.description.abstractThe effects of chloroquine on resting blood pressure, forearm blood flow (FBF), and forearm vascular resistance (FVR) and on the responses to cold stimulation were studied in healthy young adults. Chloroquine sulphate (800 mg) reduced systolic pressure and increased FBF (P<0.05) but had no effect on resting FVR. Cold immersion increased systolic pressure (from 108.8 ±1.7 mmHg to 127.8 ± 6.9 mmHg; P<0.05) diastolic pressure (from 73.4 ±2.7 to 95.2 ±6.2 mmHg; P<0.01) and FVR (from 5.9±0.9 to 13.0±l.9 a.u.; P<0.001) but reduced FBF (from 14.3±1.64 to 101 ± 1.29 ml min‐1; P<0.05). Chloroquine reduced the increase in FVR reduced by cold stimulation (P<0.01), but had little effect on the BF and FBF responses to cold stimulation. The hypotensive effect of chloroquine could be attributed, at least in part, to the observed fall in vascular resistance.en_US
dc.description.sponsorshipUniversity of Lagosen_US
dc.identifier.citationAnigbogu C. N, Adigun S. A, Adegunloye B. J, and Idong, I. (1993). Chloroquine reduces blood pressure and forearm vascular resistance and increases forearm blood flow in healthy young adults. Clinical Physiology Vol.13: 209-216.en_US
dc.identifier.issn1475-0961
dc.identifier.issn1475-097X
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6249
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subjectChloroquineen_US
dc.subjectBlood pressureen_US
dc.subjectForearm blood flowen_US
dc.subjectYoung adultsen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleChloroquine reduces blood pressure and forearm vascular resistance and increases forearm blood flow in healthy young adults.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Chloroquine Reduces Blood Pressure and Forearm Vascular Resistance and Increases Forearm Blood Flow in Healthy Young Adults.docx
Size:
22.18 KB
Format:
Microsoft Word XML
Description:
summary
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Physiology- Scholarly Publications