Therapeutic Effect of Vernonia Amygdalina Aqueous Leaf Extract on Salmonella Typhimurium-Infected Female Wistar Rats.
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Date
2022
Authors
Amushie, Ifeanyi
Ebuehi, O.A.T.
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Publisher
International Journal of Pharmaceutical and Bio-Medical Science
Abstract
This study investigated the therapeutic effects of Vernonia amygdalina aqueous leaf extract
administration on Salmonella typhimurium infected Wistar rats. Rats were infected orally by a single
dose administration of Salmonella typhimurium (1.5 x 108 CFU). Negative control groups were
infected and treated orally with vehicle (distilled water), neutral control group were not infected,
while the four test groups were treated up to 24 days with 50 mg/kg. 100 mg/kg, 150 mg/kg and 200
mg/kg body weight of aqueous leaf extract of V. amygdalina respectively. The effects of leaf extract
administration on serum markers (amino transferase activities, total protein, creatinine and bilirubin
levels), as well as histopathology of the liver and kidney tissues were also investigated. Following
in vivo studies, the 50 mg/kg dose of aqueous leaf extract of V. amygdalina was effective in
alleviating liver damage as seen in the amino transferase activity. Infection resulted in a significant
increase of amino transferase activity. The drug and plant extract helped to alleviate liver and kidney
damage from infection as observed in the organ weights and their protein content. Findings from
this study showed that the administration of this aqueous leaf extract at higher doses resulted in the
ameriolation of the tissue damage caused by the S. Typhi bacteria (from histological studies). These
results support the ethnomedicinal use of V. amygdalina, and posits that its leaves can be used in
antibacterial phytomedicine.
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Scholarly article
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Citation
Amushie, Ifeanyi and Ebuehi, O.A.T. (2022). Therapeutic Effect of Vernonia Amygdalina Aqueous Leaf Extract on Salmonella Typhimurium-Infected Female Wistar Rats. International Journal of Pharmaceutical and Bio-Medical Science 2 (7):211-222.