Antidepressant Activity of Ethanol Leaf Extract of Annona muricata L., in Sprague-Dawley Rats

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dc.contributor.authorBikomo, E.O.
dc.contributor.authorMagbagbeola, O.A.
dc.contributor.authorEbuehi, O.A.T.
dc.date.accessioned2019-09-20T11:12:23Z
dc.date.available2019-09-20T11:12:23Z
dc.date.issued2017
dc.descriptionStaff publicationsen_US
dc.description.abstractBackground: Annona muricata L. is a plant renowned for several therapeutic folklore uses, in many Caribbean communities where as revealed in literature the leaves, bark and roots are made into tea for calming effects as sedative, heart tonic and hypertensive medication. In Nigeria, these potential health benefits are untapped since A. muricata is classified as an under-utilized plant. The present study determined the antidepressant and behavioral properties of the Nigerian grown Annona muricata in Sprague-Dawley rats using the open field test and forced swim test. Methods: Rats were administered A. muricata leaf extract (50, 150 and 300mg/kg) alone, as well as in combination with imipramine or sertraline (10mg/kg) for 14days. Results: The extract was found to reduce the explorative tendencies of the rats in the open field test. In the forced swim test the extract caused a significant reduction in immobility time and increased swimming time. Combination of the extracts with imipramine or sertraline further decreased the explorative tendencies at 150mg/kg concentration and the immobility time at 150 and 300mg/kg. Conclusion: The results obtained proposed a sedative and antidepressant-like effect of ethanol extract of A. muricata, confirming the ethnomedicinal use of the ethanol leaf extract of A. muricata for the management of depression.en_US
dc.identifier.citationBikomo E. O., Ebuehi O. A., and Magbagbeola O. A. (2017). Antidepressant Activity of Ethanol Leaf Extract of Annona muricata L., in Sprague-Dawley Rats. American Journal of Biochemistry, Vol.7(1): 1-5pp.en_US
dc.identifier.otherDOI: 10.5923/j.ajb.20170701.01
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5797
dc.language.isoenen_US
dc.publisherScientific & Academic Publishingen_US
dc.relation.ispartofseriesAmerican Journal of Biochemistry;Vol.7(1)
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistryen_US
dc.subjectAnnona muricataen_US
dc.subjectAntidepressanten_US
dc.subjectImipramineen_US
dc.subjectSertralineen_US
dc.subjectOpen field testen_US
dc.subjectForced swim testen_US
dc.titleAntidepressant Activity of Ethanol Leaf Extract of Annona muricata L., in Sprague-Dawley Ratsen_US
dc.typeArticleen_US
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