Human immunodeficiency virus status in malnourished children seen at Lagos.

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dc.contributor.authorTemiye, E.O.
dc.contributor.authorAdeniyi, O.F.
dc.contributor.authorFajolu, I.B.
dc.contributor.authorOgbenna, A.A.
dc.contributor.authorLadapo, T.A.
dc.contributor.authorEsezobor, C.I.
dc.contributor.authorAkinsulie, A.O.
dc.contributor.authorMabogunje, C.A.
dc.date.accessioned2019-11-02T14:47:09Z
dc.date.available2019-11-02T14:47:09Z
dc.date.issued2018
dc.description.abstractINTRODUCTION: Human immunodeficiency virus and protein energy malnutrition are still prevalent in Nigeria and the occurrence of the two conditions together confers a poor prognosis. The aim of this study was to determine the current categories of malnutrition amongst under-5 children in Lagos, document their HIV status and determine any peculiarities in the clinical features, haematological and some biochemical profile in these children. METHODS: The study was a cross-sectional study conducted at the Paediatric departments of the Lagos University Teaching Hospital and the Massey Street Children's Hospital, both in Lagos, over a 6-month period. All the subjects had anthropometry, HIV testing, full blood count and serum proteins done. The factors associated with HIV status were determined with the logistic regression analysis. RESULTS: Two hundred and fourteen (214) malnourished children ≤5 years, including 25 (11.7%) with HIV were recruited in the study. Among the study participants, 150 (70.1%) and 54 (29.9%) had moderate and severe malnutrition, respectively. Fever, cough and diarrhea were the most common symptoms in the study participants. The haematological indices were comparable in the two groups, the serum globulin levels though higher in the HIV infected group was not statistically significantly different from the non-infected group.(p = 0.66). None of the factors explored on multivariate analysis was able to predict the occurrence of the infection in this cohort. CONCLUSION: Malnourished children remain a high risk group for HIV infection and the prevalence of the infection obtained in this group of children is still unacceptably high. Discriminatory features between malnutrition and HIV remains difficult. The presence of hyperglobulinaemia on laboratory analysis in a malnourished child may heighten the suspicion of possible underlying associated HIV infection. Screening of malnourished children for HIV infection and further longitudinal studies on malnourished children with HIV is advocated.en_US
dc.identifier.citationTemiye EO, Adeniyi OF, Fajolu IB, Ogbenna AA, Ladapo TA, Esezobor CI, Akinsulie AO, Mabogunje CA. Human immunodeficiency virus status in malnourished children seen at Lagos. PLoS One. 2018 Oct 4;13(10):e0200435..en_US
dc.identifier.otherdoi: 10.1371/journal.pone.0200435
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6681
dc.language.isoenen_US
dc.subjectMalnutritionen_US
dc.subjectHuman immunodeficiency virusen_US
dc.subjectUnder-fiveen_US
dc.subjectHaematological featuresen_US
dc.subjectBiochemical profileen_US
dc.titleHuman immunodeficiency virus status in malnourished children seen at Lagos.en_US
dc.typeArticleen_US
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