Novel intron 2 polymorphism in the melanophilin gene is in Hardy-Weinberg equilibrium and is not associated with coat color in goats

Simple item page
dc.contributor.authorAdefenwa, M.A.
dc.contributor.authorAgaviezor, B.O.
dc.contributor.authorPeters, S.O.
dc.contributor.authorWheto, M
dc.contributor.authorEkundayo, O.J.
dc.contributor.authorOkpeku, M.
dc.contributor.authorOboh, B.O.
dc.contributor.authorAdekoya, K.O.
dc.contributor.authorIkeobi, C.O.N.
dc.contributor.authorDonato, M.
dc.contributor.authorThomas, B.N.
dc.contributor.authorIkhide, G. I.
dc.date.accessioned2019-01-17T07:56:50Z
dc.date.available2019-01-17T07:56:50Z
dc.date.issued2013-09
dc.description.abstractPigmentation plays important adaptation and physiological efficiency roles in animals. In the sequence of a 648 bp fragment representing intron 1, exon 2, and part of intron 2 of the MLPH mammalian pigmentation gene, we identified a novel g.469C > G mutation in intron 2, and genotyped it in 266 Nigerian goats using PCR-RFLP analysis. The C allele had frequencies of 0.9625, 0.9804 and 0.97405 in West African Dwarf (WAD), Sahel (SH) and Red Sokoto (RS) breeds, respectively. The G allele was the highest in WAD (0.0375), followed by RS (0.02595), and then SH (0.0196). Overall low FIS and FST and high Nm values demonstrate little differentiation within and among the goat breeds at this intronic locus. This g.469C > G polymorphism in MLPH gene is the first in any goat breed and also first in Nigerian goats. Our results suggest that this intronic SNP locus is maintained at Hardy-Weinberg equilibrium (P < 0.05) and the lack of association of this SNP with coat color may indicate its neutrality in goats.en_US
dc.description.sponsorshipOpen Journal of Geneticsen_US
dc.identifier.citationAdefenwa, M. A., Agaviezor, B. O., Peters, S. O., Wheto, M., Ekundayo, O.J., Okpeku, M., Oboh, B., Adekoya, K.O., Ikeobi, C.O.N., De-Donato, M. and Ikhide, G. I. (2013). Novel intron 2 polymorphism in the melanophilin gene is in Hardy-Weinberg equilibrium and is not associated with coat colour in goats. Open Journal of Genetics. 3(3):195 – 200.en_US
dc.identifier.otherhttp://dx.doi.org/10.4236/ojgen.2013.33022
dc.identifier.urihttp://ir.unilag.edu.ng:8080/handle/123456789/3524
dc.language.isoenen_US
dc.publisherScientific research - Open Journal of Geneticsen_US
dc.subjectCoat Coloren_US
dc.subjectGoatsen_US
dc.subjectMelanophilinen_US
dc.subjectNigeriaen_US
dc.subjectIntron 2en_US
dc.subjectSNPen_US
dc.subjectPCR-RFLPen_US
dc.titleNovel intron 2 polymorphism in the melanophilin gene is in Hardy-Weinberg equilibrium and is not associated with coat color in goatsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Novel intron 2 polymorphism in the melanophilin gene is in Hardy - Weinberg equilibrum and is not associated with coat color in goats.pdf
Size:
577.52 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Cell Biology & Genetics-Scholarly Publications