Casein micelles from bovine Milk exerts Neuroprotection by stalling metabolic complications linked to oxidative brain injury.

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dc.contributor.authorErukainure, OL
dc.contributor.authorSalau, VF
dc.contributor.authorAlabi, OO
dc.contributor.authorKoorbanally, NA
dc.contributor.authorEbuehi, O.A.T.
dc.contributor.authorShahidul, Islam
dc.date.accessioned2024-05-08T15:16:07Z
dc.date.available2024-05-08T15:16:07Z
dc.date.issued2020
dc.descriptionScholarly article
dc.description.abstractCaseins are the most abundant milk proteins in mammalian species and are assembled in supra-macromolecular structures called micelles. In this study, the microstructural properties, particle size, and elemental composition of isolated casein from bovine milk and its therapeutic effect on oxidative and cholinergic activities linked to dementia in oxidative brain injury were investigated. SEM analysis of the isolated casein micelles from skimmed fresh bovine milk revealed spherical colloid aggregates, while TEM analysis revealed dispersed spherical particles with a mean size of 63.15 ± 4.77 nm. SEM-EDX analysis revealed clusters of carbon, oxygen, sulfur, copper, sodium, magnesium, potassium, iron, and selenium. Treatment of oxidative brain injury with the isolated casein micelles led to elevated levels of GSH, SOD, catalase, ENTPDase, 5’NTPase activities, while concomitantly suppressing MDA, cholesterol, HDL-c levels, acetylcholinesterase and lipase activities. Treatment with the isolated casein micelles led to complete depletion of oxidative generated lipid metabolites, while deactivating oxidative-activated lipid metabolic pathways. These results indicate the microstructural properties, particle size, elemental composition, and antioxidant neuropro tective effect of casein micelles from bovine milk. Thus, demonstrating the nutraceutical properties of milk in the management of oxidative induced cognitive impairment.
dc.identifier.citationErukainure, OL, Salau, VF, Alabi, OO, Ebuehi, O.A.T., Koorbanally, NA, Shahidul, MD(2020). Casein micelles from bovine Milk exerts Neuroprotection by stalling metabolic complications linked to oxidative brain injury. Metabolic Brain Disease 35 (5): 1417-1428.
dc.identifier.other10.1007
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/12875
dc.language.isoen_US
dc.publisherMetabolic Brain Disease
dc.titleCasein micelles from bovine Milk exerts Neuroprotection by stalling metabolic complications linked to oxidative brain injury.
dc.typeArticle
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