Synthesis and anti-tuberculosis activity of some copper(II) and cobalt(II) complexes of substituted methylene isonicotinoyl hydrazide sciff bases
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Date
2018-01-26
Authors
Dueke-Eze, C.U.
Fasina, T.M.
Familoni, O.B.
Coker, A.O.
Onubogu, C.C.
Journal Title
Journal ISSN
Volume Title
Publisher
Royal society of chemistry
Abstract
Complexes of Cu(II) and Co(II) with (E)-NI((1H-pyrrol-2-yl)methylene)isonicotinohydrazide (HL1), (E)-NI((furan-2-yl)methylene)isonicotinohydrazide (HL2) and (E)-NI((thiophene-2-yl)methylene)isonicotino hydrazide (HL3) have been synthesized and characterized by melting point, elemental analysis, infrared (IR), 1H and 13C nuclear magnetic resonance (NMR), electronic absorption spectroscopy, atomic absorption spectroscopy and molar conductivity. The results suggest that the ligands coordinated in the enol-form. All the complexes are non-electrolytes with a square planar geometry. The in-vitro antituberculosis (anti-TB) screening against Mycobacterium tuberculosis (M.TB) H37RV using the proportion method indicate that some of the metal complexes were more active against the tested organism compared to the corresponding ligands and reference compound (INH). The metal complexes of the pyrrole containing compound exhibited significant activity when compared with the reference compound.
Description
Staff Publication
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Inorganic chemistry::Coordination chemistry , isonicotinohydrazide, , schiff base , Copper(II) and Cobalt(II) complexes , Anti-tuberculosis activity
Citation
Dueke-Eze, C. U., Fasina, T. M., Familoni, O. B., Coker, A. O., & Onubogu, C. C. (2018). Synthesis and anti-tuberculosis activity of some copper(II) and cobalt(II) complexes of substituted methylene isonicotinoyl hydrazide sciff bases. Journal of Chemical Society of Nigeria, Vol.43(1).