Synthesis and anti-tuberculosis activity of some copper(II) and cobalt(II) complexes of substituted methylene isonicotinoyl hydrazide sciff bases

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dc.contributor.authorDueke-Eze, C.U.
dc.contributor.authorFasina, T.M.
dc.contributor.authorFamiloni, O.B.
dc.contributor.authorCoker, A.O.
dc.contributor.authorOnubogu, C.C.
dc.date.accessioned2019-09-06T07:48:16Z
dc.date.available2019-09-06T07:48:16Z
dc.date.issued2018-01-26
dc.descriptionStaff Publicationen_US
dc.description.abstractComplexes of Cu(II) and Co(II) with (E)-NI((1H-pyrrol-2-yl)methylene)isonicotinohydrazide (HL1), (E)-NI((furan-2-yl)methylene)isonicotinohydrazide (HL2) and (E)-NI((thiophene-2-yl)methylene)isonicotino hydrazide (HL3) have been synthesized and characterized by melting point, elemental analysis, infrared (IR), 1H and 13C nuclear magnetic resonance (NMR), electronic absorption spectroscopy, atomic absorption spectroscopy and molar conductivity. The results suggest that the ligands coordinated in the enol-form. All the complexes are non-electrolytes with a square planar geometry. The in-vitro antituberculosis (anti-TB) screening against Mycobacterium tuberculosis (M.TB) H37RV using the proportion method indicate that some of the metal complexes were more active against the tested organism compared to the corresponding ligands and reference compound (INH). The metal complexes of the pyrrole containing compound exhibited significant activity when compared with the reference compound.en_US
dc.identifier.citationDueke-Eze, C. U., Fasina, T. M., Familoni, O. B., Coker, A. O., & Onubogu, C. C. (2018). Synthesis and anti-tuberculosis activity of some copper(II) and cobalt(II) complexes of substituted methylene isonicotinoyl hydrazide sciff bases. Journal of Chemical Society of Nigeria, Vol.43(1).en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5365
dc.language.isoenen_US
dc.publisherRoyal society of chemistryen_US
dc.relation.ispartofseriesJournal of Chemical Society of Nigeria;Vol.43(1)
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Inorganic chemistry::Coordination chemistryen_US
dc.subjectisonicotinohydrazide,en_US
dc.subjectschiff baseen_US
dc.subjectCopper(II) and Cobalt(II) complexesen_US
dc.subjectAnti-tuberculosis activityen_US
dc.titleSynthesis and anti-tuberculosis activity of some copper(II) and cobalt(II) complexes of substituted methylene isonicotinoyl hydrazide sciff basesen_US
dc.typeArticleen_US
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