Semen Analysis and Morphological Study of Two Subsequent Generations of Dietary Protein Deficient Sprague Dawley Rats

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dc.contributor.authorEbuehi, O.A.T.
dc.date.accessioned2022-01-16T19:47:46Z
dc.date.available2022-01-16T19:47:46Z
dc.date.issued2020-10-22
dc.description.abstractAdequate supply of dietary protein in regular diet is an important element of a proper nutritional status as it functions in the regulation of metabolic profiles signaling the reproductive axis. Reports have highlighted the association of the amount of protein in the diet to the functioning of hypothalamic pituitary-testis axis, however its intragenerational effects are yet to be adequately explored. The study aims to analyze the effect of protein deficient diet on parameters associated with male infertility from one generation to another. Female rats in four (4) groups (n=10) were fed different ration of protein in their diet (PD) as formulated: 21%PD, 10%PD, 5%PD and control diet (rat chow), through gestation and lactation to first and second generations, while the male offspring sustained on the maternal diet after weaning were used for analysis. Sperm morphology and motility were evaluated using a light microscope and a computer-assisted semen analysis. The percentage of motile spermatozoa, morphological characteristics and histology in the deficient groups (5%, 10%PD) appeared normal as compared to control in the first generation, showing an adaptive response while second generation was presented with significantly altered fertility parameters of the male offspring. It is suggested that in a deficiency status especially at the critical phase of development, certain deleterious effects which may be adaptive or phenotypic can serve to reduce the fertility efficiency in the male offspring at both F1 and F2- generation.en_US
dc.identifier.citationNosarieme Omoregie Abey* , Osaretin Albert Taiwo Ebuehi Department of Biochemistry, College of Medicine, University of Lagosen_US
dc.identifier.issn2456-7132
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10461
dc.language.isoen_USen_US
dc.publisherInternational Annals of Scienceen_US
dc.relation.ispartofseries;Volume 10, Issue 1, pp. 85-91, 2021
dc.subjectSemen, motility, protein deficiency, testicular morphology, testosteroneen_US
dc.titleSemen Analysis and Morphological Study of Two Subsequent Generations of Dietary Protein Deficient Sprague Dawley Ratsen_US
dc.typeArticleen_US
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