Synthesis and Antimicrobial Activity of Schiff Bases derived from substituted Salicyladehyde with 2-aminophenol and 2-aminothiophenol
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Date
2013-01
Authors
Fasina, T.M.
Ejiah, F.N.
Dueke-Eze, C.U.
Idika, N.
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Scientific Research and Development
Abstract
Schiff bases of substituted salicylaldehydes namely 5-bromosalicylaldehyde and 5-nitrosalicyladehyde with 2-
aminophenol and 2-aminothiophenol have been synthesized and characterized by IR, NMR and elemental
analysis. All synthesized compounds were screened for their antimicrobial activity against some clinically
important bacteria; Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Staphylococcus
aureus ATCC25923, Enterococcus feacalis ATCC 29212 by Agar ditch method using N,N’-dimethylformamide
(DMF) and 1,4-dioxane as solvents. Activity data shows a higher activity of the compounds in DMF with the
bromo substituted imines more potent than the nitro substituted compounds
Description
Staff publications
Keywords
2-aminophenol , 2-aminothiophenol , Schiff base , Antimicrobial activity , Research Subject Categories::NATURAL SCIENCES::Chemistry , Research Subject Categories::NATURAL SCIENCES::Chemistry
Citation
Fasina, T.M, Elija, F.N & Dueke-Eze, C.U and Idika, N. (2013). Synthesis and Antimicrobial Activity of Schiff Bases Derived from Substituted Salicylaldehyde with 2-aminophenol and 2-aminothiophenol. Journal of Scientific Research and Development. Vol.14. 95-98pp.