Anti-Inflammatory properties of the fruit of allanblanckia floribunda oliv. (Guttiferae)

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dc.contributor.authorAyoola, GA.
dc.contributor.authorAkpanika, GA.
dc.contributor.authorAwobajo, FO.
dc.contributor.authorSofidiya, MO.
dc.contributor.authorOsunkalu, VO.
dc.contributor.authorCoker, HAB.
dc.contributor.authorOdugbemi, TO.
dc.date.accessioned2020-11-17T09:05:48Z
dc.date.available2020-11-17T09:05:48Z
dc.date.issued2009
dc.descriptionStaff Publicationsen_US
dc.description.abstractThe present study aims to investigate the anti-inflammatory properties of the fruits of Allanblackia floribunda Oliv. [Guttiferae]. The fruits are traditionally used in the treatment of anti-inflammatory conditions. The methanolic extracts of the fruits (100-400 mg/kg, p.o) inhibited carrageenan induced paw oedema in rats in a dose dependent manner. At 400 mg/kg A. floribunda(AF) produced an inhibition of 76.9% compared to 64.3% for indomethacin (10 mg/kg). Acetylsalicylic acid(100 mg/kg - ASA) did not show significant activity in the inhibition of the neurogenic phase, butwas more active thanA. floribunda in the inhibition of the inflammatory phase of formalin-induce pain.A. floribunda was not active as an anti-inflammatory agent up to 2 h in the histamine-induced rat paw oedema but a significant reduction in paw size was observed after 2 h. This suggests that AF was more active in the later phase of the inflammatory process. AF also reduced hot plate latency in a dose dependent manner. Hot plate latency of 26.8 s was recorded for AF at 400 mg/kg compared to 18.12 s for normal saline and 30.6 s for ASA. LD,, value was determined in Swiss albino mice as 20 g/kg and so can be regarded as relatively safe.en_US
dc.identifier.citationAyoola GA, Akpanika GA, Awobajo FO, Sofidiya MO, Osunkalu VO, Coker H.A. & Odugbemi TO (2009). Anti-Inflammatory properties of the fruit of allanblanckia floribunda oliv. (Guttiferae). Botany Research International, 2(1):21-26.en_US
dc.identifier.issn2221-3635
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/8941
dc.language.isoenen_US
dc.publisherBotany Research Internationalen_US
dc.relation.ispartofseriesBotany Research International;Vol.2(1)
dc.subjectAllanblackia floribundaen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectRat paw oedemaen_US
dc.subjectAnalgesicen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleAnti-Inflammatory properties of the fruit of allanblanckia floribunda oliv. (Guttiferae)en_US
dc.typeArticleen_US
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