Serum ferritin levels in adults with sicklecell disease in Lagos, Nigeria

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dc.contributor.authorAkinbami, A.A
dc.contributor.authorDosunmu, A.O
dc.contributor.authorAdediran, A.A
dc.contributor.authorOshinaike, O.O
dc.contributor.authorOsunkalu, V.O
dc.contributor.authorAjibola, S.O
dc.contributor.authorArogundade, O.M
dc.date.accessioned2020-01-28T14:48:22Z
dc.date.available2020-01-28T14:48:22Z
dc.date.issued2013-05-21
dc.descriptionStaff publicationsen_US
dc.description.abstractBackground: Serum ferritin is considered to be one of the most important tools in the measurement of iron balance in steady-state sickle cell disease. Increased gastrointestinal absorption of iron has been reported in sickle cell disease because of the associated chronic hemolysis, and it is also thought that repeated red cell transfusion consequent to chronic hemolysis and anemia causes excessive iron levels. The aim of this study was to determine overall and gender-specific mean ferritin levels in patients with steady-state sickle cell disease in order to establish the prevalence of iron deficiency and overload.Methods: This was a cross-sectional study in homozygous patients with sickle cell disease attending the sickle cell clinic at Lagos State University Teaching Hospital, Ikeja. A 5 mL blood sample was collected in plain bottles from consenting participants during steady-state periods. The serum was separated and analyzed for ferritin by enzyme-linked immunosorbent assay. Another 5 mL sample was collected for a full blood count, done on the same day of collection, to determine red blood cell indices, ie, mean cell volume, mean cell hemoglobin concentration, and mean corpuscular hemoglobin concentration. The Pearson Chi-square test was used for statistical analysis. The differences were considered to be statistically significant when P was ,0.05.Results: In total, 103 patients were recruited for this study and comprised 58 women (56.40%) and 45 men (43.70%). The overall mean ferritin concentration was 93.72 ± 92.24 ng/mL. The mean ferritin concentration in the women was 92.00 ± 88.07 ng/mL and in men was 96.41 ± 99.80 ng/mL. Only eight (7.76%) of the 103 patients had a serum ferritin level , 15 ng/mL, while two subjects (1.94%) had a serum a ferritin level . 300 ng/mL. Ninety-three subjects (90.29%) had serum ferritin within the normal reference range of 15–300 ng/mL.Conclusion: In this study, 90% of subjects with sickle cell disease had normal iron stores; serum ferritin was higher in men than in women, and iron deficiency was more common than overload in the disease.en_US
dc.identifier.citationAkinbami, AA, Dosunmu, AO, Adediran, AA, Oshinaike, OO, Osunkalu VO, Ajibola SO, Arogundade OM. (2013). Serum ferritin levels in adults with sicklecell disease in Lagos, Nigeria. Journal of Blood Medicine, 4, 59–63.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7541
dc.language.isoenen_US
dc.publisherJournal of Blood Medicine. Dove Medical Press Ltd.en_US
dc.relation.ispartofseriesJournal of Blood Medicine;Vol.4
dc.subjectserum ferritin levelsen_US
dc.subjectsickle cell diseaseen_US
dc.subjectIron balanceen_US
dc.subjectGeneticsen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleSerum ferritin levels in adults with sicklecell disease in Lagos, Nigeriaen_US
dc.typeArticleen_US
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