The Physicochemical and antibacterial Properties of Ciprofloxacin-Mg2+ complex.
No Thumbnail Available
Nig. Q. J. Hosp. Med.
Purpose: Co-administration of quinolone antibiotics with cation-containing medicaments such as, antacids has been reported to influence the overall bioavailability leading to subtherapeutic plasma concentrations of these antibiotics in humans. Objectives of the study: The present work was designed to evaluate the binding constant, binding molar ratio, influence of temperature on the binding constant of ciprofloxacin-Mg2+ and to determine the antimicrobial activity of ciprofloxacin and ciprofloxacin-Mg2+. Methods: Job's method of continuous variation and Benesi-Hildebrand equation were adopted to determine the molar ratio and stability constant respectively. The antibacterial activity was determined.by the Agar diffusion method. Results: A complexation molar ratio of 1 :1 was obtained for ciprofloxacin-Mg2+ complex. The stability constants were 3.59 and 3.50 at 25°C and 60°C respectively. There was a significant difference between the zones of inhibition of ciprofloxacin-Mg2+ complex and that of ciprofloxacin alone against E. coli, P. aeruginosa and S. aureus (p<0.05). This difference showed that the complex formed was not as active as ciprofloxacin. Conclusion: The present studies have shown that ciprofloxacin readily complex with Mg2+ and that the stability constant was temperature dependent. The antibacterial activity of ciprofloxacin was markedly reduced in the presence of Mg2+. Concomitant administration of ciprofloxacin Mg2+ containing medicaments should be avoided to prevent resistance. Key words: Ciprofloxacin-Mg2+ complex, stability constant, antibacterial activity.
Stability constant , Antibacterial activity , Antibiotics , Plasma concentrations , Research Subject Categories::PHARMACY::Pharmaceutical chemistry
Adepoju-Bello AA, Coker HAB, Eboka CJ, Abioye AO, Ayoola GA (2008). The Physicochemical and antibacterial Properties of Ciprofloxacin-Mg2+ complex. Nig. Q. J. Hosp. Med., 18 (3): 133-136.