The Physicochemical and antibacterial Properties of Ciprofloxacin-Mg2+ complex.
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Date
2008
Authors
Adepoju-Bello A.A.
Coker H.A.B.
Eboka C.J.
Abioye A.O.
Ayoola G.A.
Journal Title
Journal ISSN
Volume Title
Publisher
Nig. Q. J. Hosp. Med.
Abstract
Purpose: Co-administration of quinolone antibiotics with cation-containing medicaments such as, antacids has been
reported to influence the overall bioavailability leading to subtherapeutic plasma concentrations of these antibiotics in humans.
Objectives of the study: The present work was designed to evaluate the binding constant, binding molar ratio,
influence of temperature on the binding constant of ciprofloxacin-Mg2+ and to determine the antimicrobial activity of ciprofloxacin and ciprofloxacin-Mg2+.
Methods: Job's method of continuous variation and Benesi-Hildebrand equation were adopted to determine the molar ratio and stability constant respectively. The antibacterial activity was determined.by the Agar diffusion method.
Results: A complexation molar ratio of 1 :1 was obtained for ciprofloxacin-Mg2+ complex. The stability constants were
3.59 and 3.50 at 25°C and 60°C respectively. There was a significant difference between the zones of inhibition of
ciprofloxacin-Mg2+ complex and that of ciprofloxacin alone against E. coli, P. aeruginosa and S. aureus (p<0.05).
This difference showed that the complex formed was not as active as ciprofloxacin.
Conclusion: The present studies have shown that ciprofloxacin readily complex with Mg2+ and that the stability
constant was temperature dependent. The antibacterial activity of ciprofloxacin was markedly reduced in the
presence of Mg2+. Concomitant administration of ciprofloxacin Mg2+ containing medicaments should be avoided to prevent resistance.
Key words: Ciprofloxacin-Mg2+ complex, stability constant, antibacterial activity.
Description
Scholarly articles
Keywords
Stability constant , Antibacterial activity , Antibiotics , Plasma concentrations , Research Subject Categories::PHARMACY::Pharmaceutical chemistry
Citation
Adepoju-Bello AA, Coker HAB, Eboka CJ, Abioye AO, Ayoola GA (2008). The Physicochemical and antibacterial Properties of Ciprofloxacin-Mg2+ complex. Nig. Q. J. Hosp. Med., 18 (3): 133-136.