The Physicochemical and antibacterial Properties of Ciprofloxacin-Mg2+ complex.
| dc.contributor.author | Adepoju-Bello A.A. | |
| dc.contributor.author | Coker H.A.B. | |
| dc.contributor.author | Eboka C.J. | |
| dc.contributor.author | Abioye A.O. | |
| dc.contributor.author | Ayoola G.A. | |
| dc.date.accessioned | 2022-01-08T16:54:15Z | |
| dc.date.available | 2022-01-08T16:54:15Z | |
| dc.date.issued | 2008 | |
| dc.description | Scholarly articles | en_US |
| dc.description.abstract | Purpose: Co-administration of quinolone antibiotics with cation-containing medicaments such as, antacids has been reported to influence the overall bioavailability leading to subtherapeutic plasma concentrations of these antibiotics in humans. Objectives of the study: The present work was designed to evaluate the binding constant, binding molar ratio, influence of temperature on the binding constant of ciprofloxacin-Mg2+ and to determine the antimicrobial activity of ciprofloxacin and ciprofloxacin-Mg2+. Methods: Job's method of continuous variation and Benesi-Hildebrand equation were adopted to determine the molar ratio and stability constant respectively. The antibacterial activity was determined.by the Agar diffusion method. Results: A complexation molar ratio of 1 :1 was obtained for ciprofloxacin-Mg2+ complex. The stability constants were 3.59 and 3.50 at 25°C and 60°C respectively. There was a significant difference between the zones of inhibition of ciprofloxacin-Mg2+ complex and that of ciprofloxacin alone against E. coli, P. aeruginosa and S. aureus (p<0.05). This difference showed that the complex formed was not as active as ciprofloxacin. Conclusion: The present studies have shown that ciprofloxacin readily complex with Mg2+ and that the stability constant was temperature dependent. The antibacterial activity of ciprofloxacin was markedly reduced in the presence of Mg2+. Concomitant administration of ciprofloxacin Mg2+ containing medicaments should be avoided to prevent resistance. Key words: Ciprofloxacin-Mg2+ complex, stability constant, antibacterial activity. | en_US |
| dc.identifier.citation | Adepoju-Bello AA, Coker HAB, Eboka CJ, Abioye AO, Ayoola GA (2008). The Physicochemical and antibacterial Properties of Ciprofloxacin-Mg2+ complex. Nig. Q. J. Hosp. Med., 18 (3): 133-136. | en_US |
| dc.identifier.issn | 0189-2657 | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/10031 | |
| dc.language.iso | en | en_US |
| dc.publisher | Nig. Q. J. Hosp. Med. | en_US |
| dc.subject | Stability constant | en_US |
| dc.subject | Antibacterial activity | en_US |
| dc.subject | Antibiotics | en_US |
| dc.subject | Plasma concentrations | en_US |
| dc.subject | Research Subject Categories::PHARMACY::Pharmaceutical chemistry | en_US |
| dc.title | The Physicochemical and antibacterial Properties of Ciprofloxacin-Mg2+ complex. | en_US |
| dc.type | Article | en_US |